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They seem to report results from human subjects as well. > Human brain tissue from 9 individuals with COVID-19 or SARS-CoV-2 infection exhibits the same patter

They seem to report results from human subjects as well. > Human brain tissue from 9 individuals with COVID-19 or SARS-CoV-2 infection exhibits the same pattern of prominent white matter-selective microglial reactivity. [...] Humans experiencing long-COVID with cognitive symptoms (48 subjects) similarly demonstrate elevated CCL11 levels compared to those with long-COVID who lack cognitive symptoms (15 subjects).

timr 5y ago
Figure 3 shows some CD68 staining of a handful of human brain samples from people who died (not necessarily from Covid), and were subsequently found to test positive for Covid. The argument is that this is one sign of inflammation in the white matter (axons), but not gray matter (neural bodies) of these samples. While this allows them to claim some connection to humans in a paper that is almost entirely about mice, it's so different from the bulk of the experiments that it is essentially a tangent. Edit: Out of curiosity, I dug up the paper describing the people from whom these 9 samples were taken. https://www.nejm.org/doi/full/10.1056/NEJMc2033369 https://www.nejm.org/doi/full/10.1056/NEJMc2033369 These patients...let's just say they were not well prior to Covid: > We performed conventional histopathological examination of the brains of 18 patients. Fourteen patients had chronic illnesses, including diabetes and hypertension, and 11 had been found dead or had died suddenly and unexpectedly. Of the 16 patients with available medical histories, 1 had delirium, 5 had mild respiratory symptoms, 4 had acute respiratory distress syndrome, 2 had pulmonary embolism, and the symptoms were not known in 3 I can't tell which of these patients' samples were used in this latest study, but...there's a lot going on. One of the patients was a meth addict, and another was a heroin addict, yet another was an alcoholic, and two others had recurrent seizures from prior head injuries: https://www.nejm.org/doi/suppl/10.1056/NEJMc2033369/suppl_file/nejmc2033369_appendix.pdf https://www.nejm.org/doi/suppl/10.1056/NEJMc2033369/suppl_fi... This just goes to show that you must dig into results like these before drawing any conclusion. If five of the nine samples used here were from people with drug addiction and chronic brain diseases, would it change your perception of the results?
- postingposts 5y ago

timr 5y ago

Figure 3 shows some CD68 staining of a handful of human brain samples from people who died (not necessarily from Covid), and were subsequently found to test positive for Covid. The argument is that this is one sign of inflammation in the white matter (axons), but not gray matter (neural bodies) of these samples. While this allows them to claim some connection to humans in a paper that is almost entirely about mice, it's so different from the bulk of the experiments that it is essentially a tangent. Edit: Out of curiosity, I dug up the paper describing the people from whom these 9 samples were taken. https://www.nejm.org/doi/full/10.1056/NEJMc2033369 https://www.nejm.org/doi/full/10.1056/NEJMc2033369 These patients...let's just say they were not well prior to Covid: > We performed conventional histopathological examination of the brains of 18 patients. Fourteen patients had chronic illnesses, including diabetes and hypertension, and 11 had been found dead or had died suddenly and unexpectedly. Of the 16 patients with available medical histories, 1 had delirium, 5 had mild respiratory symptoms, 4 had acute respiratory distress syndrome, 2 had pulmonary embolism, and the symptoms were not known in 3 I can't tell which of these patients' samples were used in this latest study, but...there's a lot going on. One of the patients was a meth addict, and another was a heroin addict, yet another was an alcoholic, and two others had recurrent seizures from prior head injuries: https://www.nejm.org/doi/suppl/10.1056/NEJMc2033369/suppl_file/nejmc2033369_appendix.pdf https://www.nejm.org/doi/suppl/10.1056/NEJMc2033369/suppl_fi... This just goes to show that you must dig into results like these before drawing any conclusion. If five of the nine samples used here were from people with drug addiction and chronic brain diseases, would it change your perception of the results?

postingposts 5y ago