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How is it same? I thought traditional vaccines are about injecting the diluted viral load to trigger immune response whereas mRNA vaccine is about injecting rna

How is it same? I thought traditional vaccines are about injecting the diluted viral load to trigger immune response whereas mRNA vaccine is about injecting rna fragment that hijack your body cell to make the foreign protein to trigger immune response. Isn't the whole mechanism different?

bawolff 5y ago
> I thought traditional vaccines are about injecting the diluted viral load Umm,no. I guess live vaccines are kind of like that, but its still a misleading description, and most "traditional" vaccines aren't live vaccines.
tjpnz 5y ago
Your original comment was regarding the immune system, in that vein there is no difference in how it trains itself to recognise the inactive virus versus the spike protein made in the body.
TacticalMalice 5y ago
Attenuated viral vaccines, against measles for example, also hijack body cells to make foreign proteins to trigger immune responses.
yazaddaruvala 5y ago
> about injecting the diluted viral load to trigger immune response A “diluted viral load” is a very unsafe vaccine. “diluted” means “less of” and basically means infect ourself “with less of the virus” and hope for the best. The virus by definition is an unsafe mRNA payload (sometimes the virus will first burrows into our DNA which then creates the mRNA) that will hijack our cells and reproduce itself until there is a large enough viral load that can trigger immune response. For an effective and safe “old-school” vaccine we would need a “dead or disabled large viral load”. “dead or disabled” typically means “can’t reproduce” and/or “can’t produce the problem viral proteins” and basically means the amount of virus in our bodies at all times is roughly the amount in the injection. This has to be a large enough “viral load” to trigger immune response. The new mRNA vaccines are attempting to be safe mRNA payloads pretending to be the unsafe virus by using very small parts of the unsafe virus (e.g. only the spike protein) but this safe mRNA payload will “reproduce” inside our cells creating a lot of spike protein. They create a large enough “viral load” to trigger immune response. There is no body without mRNA and there are basically no viruses that don’t leverage mRNA and therefore all previous vaccines used mRNA we just didn’t have good technology to use it directly. I hope this helps clarify that “diluted viral load” is an incorrect oversimplification for old/new vaccine science. To understand “old school” vaccines, you would be better off with “boiled viral load” or “cooked viral load” as the oversimplification.

bawolff 5y ago

> I thought traditional vaccines are about injecting the diluted viral load Umm,no. I guess live vaccines are kind of like that, but its still a misleading description, and most "traditional" vaccines aren't live vaccines.

tjpnz 5y ago

Your original comment was regarding the immune system, in that vein there is no difference in how it trains itself to recognise the inactive virus versus the spike protein made in the body.

TacticalMalice 5y ago

Attenuated viral vaccines, against measles for example, also hijack body cells to make foreign proteins to trigger immune responses.

yazaddaruvala 5y ago

> about injecting the diluted viral load to trigger immune response A “diluted viral load” is a very unsafe vaccine. “diluted” means “less of” and basically means infect ourself “with less of the virus” and hope for the best. The virus by definition is an unsafe mRNA payload (sometimes the virus will first burrows into our DNA which then creates the mRNA) that will hijack our cells and reproduce itself until there is a large enough viral load that can trigger immune response. For an effective and safe “old-school” vaccine we would need a “dead or disabled large viral load”. “dead or disabled” typically means “can’t reproduce” and/or “can’t produce the problem viral proteins” and basically means the amount of virus in our bodies at all times is roughly the amount in the injection. This has to be a large enough “viral load” to trigger immune response. The new mRNA vaccines are attempting to be safe mRNA payloads pretending to be the unsafe virus by using very small parts of the unsafe virus (e.g. only the spike protein) but this safe mRNA payload will “reproduce” inside our cells creating a lot of spike protein. They create a large enough “viral load” to trigger immune response. There is no body without mRNA and there are basically no viruses that don’t leverage mRNA and therefore all previous vaccines used mRNA we just didn’t have good technology to use it directly. I hope this helps clarify that “diluted viral load” is an incorrect oversimplification for old/new vaccine science. To understand “old school” vaccines, you would be better off with “boiled viral load” or “cooked viral load” as the oversimplification.