3 ms·

I had 3x Moderna. The last two shots made me feel like shit for 36h and 24h respectively. It wasn’t fun but ok. A friend of mine, same age, is in a couple wher

I had 3x Moderna. The last two shots made me feel like shit for 36h and 24h respectively. It wasn’t fun but ok. A friend of mine, same age, is in a couple where he isn’t vaccinated and she is (Pfizer). Of course he got sick last month and contaminated her because they live together. He had to take 10 days off and felt like shit the whole time, unable to do anything. She kept working because since sh was vaccinated she had very very mild symptoms that didn’t hinder her. Anecdotal evidence is anecdotal, and you don’t even mention what vaccine you got. What I’m considering doing for the next booster is to check how many antigens I still have before deciding if I take the booster when it’s due or wait a bit longer (barring a virulent mutation that would change the decision making). In any case, I’ll take 24–36h of flu like symptoms (without having an actual virus damaging my body) any day over 7–10 days of agony like my friend went through.

nradov 5y ago
Which antigens are you referring to? If you mean antibody titers, that doesn't actually tell you much about your immunity level. In practice cellular immunity is more important, but it's not easy to assay. https://peterattiamd.com/covid-part2/ https://peterattiamd.com/covid-part2/
- ornornor 5y ago
  I was going to leave that up to my doctor because they know much more than I do. What I meant is that I’d want to check how much I need the next booster (or wait if I don’t) before actually getting it.
  - nradov 5y ago
    You're missing the point. You can take your doctor's advice, or not. But that advice will necessarily be generalized based on public health guidelines and not personalized based on any relevant quantitative tests. Your doctor doesn't have access to the assays necessary to accurately measure cellular immunity levels. Those are rather complex and typically only used in small research studies. Antibody levels will always decline over time after infection or vaccination. A third booster might have some long-term benefits for certain patients but beyond that trying to keep those levels elevated with repeated boosters is pointless for most patients.

nradov 5y ago

Which antigens are you referring to? If you mean antibody titers, that doesn't actually tell you much about your immunity level. In practice cellular immunity is more important, but it's not easy to assay. https://peterattiamd.com/covid-part2/ https://peterattiamd.com/covid-part2/

ornornor 5y ago
I was going to leave that up to my doctor because they know much more than I do. What I meant is that I’d want to check how much I need the next booster (or wait if I don’t) before actually getting it.
- nradov 5y ago
  You're missing the point. You can take your doctor's advice, or not. But that advice will necessarily be generalized based on public health guidelines and not personalized based on any relevant quantitative tests. Your doctor doesn't have access to the assays necessary to accurately measure cellular immunity levels. Those are rather complex and typically only used in small research studies. Antibody levels will always decline over time after infection or vaccination. A third booster might have some long-term benefits for certain patients but beyond that trying to keep those levels elevated with repeated boosters is pointless for most patients.