3 ms·

Because at least for Vitamin D in general, there are a bunch of studies, and overall it looks like it probably doesn't work[0]. I'd recommend taking it anyway,

by lkbm 5y ago

Because at least for Vitamin D in general, there are a bunch of studies, and overall it looks like it probably doesn't work[0]. I'd recommend taking it anyway, but there are more than two studies and the results are not solidly on the side of "it works". [0] https://astralcodexten.substack.com/p/covidvitamin-d-much-more-than-you https://astralcodexten.substack.com/p/covidvitamin-d-much-mo...

nradov 5y ago
That article is badly outdated and incomplete. I recommend reading through this more comprehensive list of studies. https://vitamin-d-covid.shotwell.ca/ https://vitamin-d-covid.shotwell.ca/ Maintaining adequate vitamin D levels probably does "work" in the sense of reducing the risk of severe symptoms. It is not a magic cure and shouldn't be relied upon as an alternative to vaccines or other therapies.
edejong 5y ago
I would like to take time to debunk that whole article, but let's just focus on the article [1] I shared and to debunk his argumentation for the preprint article [2]. To begin with, you have to understand that the vitamin D3 supplement we take is usually cholecalciferol, which is metabolised by our body over a period of weeks into calcifediol. The key takeaway is that the usual supplement takes weeks to be effective. The RCT in article [1] is so strong because it supplements calcifediol at hospital intake, meaning the supplementation is immediately effective. So you can see that as a proxy for having supplemented with normal vitamin D for a couple of weeks prior. In article [2], the one he is promoting, cholecalciferol (normal vitamin D) is supplemented. This means it is unlikely that it will have a significant effect during the first weeks of admission. [1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456194/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456194/ [2] https://www.medrxiv.org/content/10.1101/2020.11.16.20232397v1 https://www.medrxiv.org/content/10.1101/2020.11.16.20232397v...

by lkbm 5y ago

nradov 5y ago

That article is badly outdated and incomplete. I recommend reading through this more comprehensive list of studies. https://vitamin-d-covid.shotwell.ca/ https://vitamin-d-covid.shotwell.ca/ Maintaining adequate vitamin D levels probably does "work" in the sense of reducing the risk of severe symptoms. It is not a magic cure and shouldn't be relied upon as an alternative to vaccines or other therapies.

edejong 5y ago

I would like to take time to debunk that whole article, but let's just focus on the article [1] I shared and to debunk his argumentation for the preprint article [2]. To begin with, you have to understand that the vitamin D3 supplement we take is usually cholecalciferol, which is metabolised by our body over a period of weeks into calcifediol. The key takeaway is that the usual supplement takes weeks to be effective. The RCT in article [1] is so strong because it supplements calcifediol at hospital intake, meaning the supplementation is immediately effective. So you can see that as a proxy for having supplemented with normal vitamin D for a couple of weeks prior. In article [2], the one he is promoting, cholecalciferol (normal vitamin D) is supplemented. This means it is unlikely that it will have a significant effect during the first weeks of admission. [1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456194/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456194/ [2] https://www.medrxiv.org/content/10.1101/2020.11.16.20232397v1 https://www.medrxiv.org/content/10.1101/2020.11.16.20232397v...