3 ms·
a diversity of binding sites, almost none of which (outside spike protein binders) actually neutralize the virus.
by hcknwscommenter 5y ago
a diversity of binding sites, almost none of which (outside spike protein binders) actually neutralize the virus.
- bpodgursky 5y agoIf there as no difference, the Moderna vaccine would be as effective as infection at preventing reinfection, but it isn't. So what drives the difference? (yes, it is highly effective at preventing hospitalization and death, but it's clearly a muted response)
- hcknwscommenter 5y ago"but it isn't" That is simply untrue. You are likely referring to the Israeli data which has not reproduced. Proof: https://www.cdc.gov/mmwr/volumes/70/wr/mm7044e1.htm?s_cid=mm7044e1_w https://www.cdc.gov/mmwr/volumes/70/wr/mm7044e1.htm?s_cid=mm... . Bottom line: natural immunity is not so great. Get vaccinated. What drives the difference? Just speculating, but during natural infection the immune system will generate a huge number of disparate antibodies that do nothing because when they bind their targets it doesn't block the virus. Vaccination localizes the immune response to the key cell-receptor binding sites.