26 ms·

Seems like a day late and a dollar short on this effort.

thehappypm 5y ago
Um, Omicron was discovered 2 months ago.
fpgaminer 5y ago
It's not about Omicron today, it's about Omicron's descendants. Before Omicron, two doses provided >90% protection, and held up well against Delta. Now, two doses provides only 40% protection against Omicron. Whereas three doses bumps that back up to 80%. Given these trends it's clear that we need a plan forward, just in case, for whatever comes on the menu next year. It's likely to be an Omicron descendant, since Omicron is dominating the gene pool. It's a reasonable assumption that an Omicron derived vaccine would have provided >90% protection against Omicron. And so, reasonably, being Omicron-boosted in the future should provide something like 80% protection against whatever the next dominate strain will be, whereas the existing boosters might not fare as well. That's the hope anyway.
- nradov 5y ago
  If you're going to state vaccine effectiveness percentages then you need to define the endpoint. Stating that it provides 40% protection against Omicron is meaningless. Is that against PCR confirmed infection, symptomatic infection, hospitalization, death, or something else? And over what time period? The reality is that two doses of the existing mRNA vaccines still provide very good protection against severe disease for the vast majority of patients. https://peterattiamd.com/covid-part2/ https://peterattiamd.com/covid-part2/
- EricE 5y ago
  Omnicron is so mild for the VAST majority of people that frankly the best thing that can happen is for it to just spread and we all get to heard immunity that much faster. Thankfully it's so much more virulent that this is going to happen whether we like it or not. Makes me think of the old chicken pox parties when I was a kid. The virus is carried by animals and it's not going away. So we had better start figuring out how to more reasonably live with it, stop with the asinine one size fits all solutions; many of them (like cloth masks) that are actually anti-science based and stop destroying so many people's lives - especially children - I can't imagine being a child in todays idiotic overreactive and politically energized environments, especially since children had the least to fear even from the original, pretty nasty virus. Yes, there are even kids that are more at risk - but you don't screw everyone - you protect the vulnerable. Common sense seems to be utterly out the window as everyone is running around panicking; it's beyond nuts.
  - foxyv 5y ago
    Emergency rooms and ICUs are barely keeping up right now. Full infection of the country will be devastating. ER and ICU staffing is already way short of what we need. Supplies are low. An omicron vaccine will help stave this off for now. In addition, the smaller the pool of infected individuals, the slower the mutation rate will be.
    - xiphias2 5y ago
      As a Pfizer triple vaccinated person I would prefer getting Omicron to its descendant that is even farther away from what I'm protected from. The immune system is capable of reacting to series of smaller mutations much better than a big one. This is one of the main ways of developing a series of vaccines that lead to HIV immunity right now.
    - EricE 5y ago
      Emergency rooms are overloaded only because most states have ignored treatments that are effective at not only keeping people out of the hospital but resolving symptoms within a week, readily available, not costly (aha!) and very safe, long used drugs that are well understood. A self inflicted wound is hardly a reason for continued panic. Now that the brain dead vaccine mandates are being shot down staffing should also start to resolve itself. Again, the VAST majority of issues with COVID are self inflicted - driven by politics and severely misguided social pressure.
- r00fus 5y ago
  Omicron BA.2 is already here [1]. In Denmark, it's already >50% of the cases. [1] https://deadline.com/2022/01/omicron-offshoot-ba2-in-us-1234918884/ https://deadline.com/2022/01/omicron-offshoot-ba2-in-us-1234...

Um, Omicron was discovered 2 months ago.

It's not about Omicron today, it's about Omicron's descendants. Before Omicron, two doses provided >90% protection, and held up well against Delta. Now, two doses provides only 40% protection against Omicron. Whereas three doses bumps that back up to 80%. Given these trends it's clear that we need a plan forward, just in case, for whatever comes on the menu next year. It's likely to be an Omicron descendant, since Omicron is dominating the gene pool. It's a reasonable assumption that an Omicron derived vaccine would have provided >90% protection against Omicron. And so, reasonably, being Omicron-boosted in the future should provide something like 80% protection against whatever the next dominate strain will be, whereas the existing boosters might not fare as well. That's the hope anyway.

nradov 5y ago
If you're going to state vaccine effectiveness percentages then you need to define the endpoint. Stating that it provides 40% protection against Omicron is meaningless. Is that against PCR confirmed infection, symptomatic infection, hospitalization, death, or something else? And over what time period? The reality is that two doses of the existing mRNA vaccines still provide very good protection against severe disease for the vast majority of patients. https://peterattiamd.com/covid-part2/ https://peterattiamd.com/covid-part2/
EricE 5y ago
Omnicron is so mild for the VAST majority of people that frankly the best thing that can happen is for it to just spread and we all get to heard immunity that much faster. Thankfully it's so much more virulent that this is going to happen whether we like it or not. Makes me think of the old chicken pox parties when I was a kid. The virus is carried by animals and it's not going away. So we had better start figuring out how to more reasonably live with it, stop with the asinine one size fits all solutions; many of them (like cloth masks) that are actually anti-science based and stop destroying so many people's lives - especially children - I can't imagine being a child in todays idiotic overreactive and politically energized environments, especially since children had the least to fear even from the original, pretty nasty virus. Yes, there are even kids that are more at risk - but you don't screw everyone - you protect the vulnerable. Common sense seems to be utterly out the window as everyone is running around panicking; it's beyond nuts.
- foxyv 5y ago
  Emergency rooms and ICUs are barely keeping up right now. Full infection of the country will be devastating. ER and ICU staffing is already way short of what we need. Supplies are low. An omicron vaccine will help stave this off for now. In addition, the smaller the pool of infected individuals, the slower the mutation rate will be.
  - xiphias2 5y ago
    As a Pfizer triple vaccinated person I would prefer getting Omicron to its descendant that is even farther away from what I'm protected from. The immune system is capable of reacting to series of smaller mutations much better than a big one. This is one of the main ways of developing a series of vaccines that lead to HIV immunity right now.
  - EricE 5y ago
    Emergency rooms are overloaded only because most states have ignored treatments that are effective at not only keeping people out of the hospital but resolving symptoms within a week, readily available, not costly (aha!) and very safe, long used drugs that are well understood. A self inflicted wound is hardly a reason for continued panic. Now that the brain dead vaccine mandates are being shot down staffing should also start to resolve itself. Again, the VAST majority of issues with COVID are self inflicted - driven by politics and severely misguided social pressure.
r00fus 5y ago
Omicron BA.2 is already here [1]. In Denmark, it's already >50% of the cases. [1] https://deadline.com/2022/01/omicron-offshoot-ba2-in-us-1234918884/ https://deadline.com/2022/01/omicron-offshoot-ba2-in-us-1234...