> We know our mRNA vaccines are safe and they worked great against Delta. Yes and no. We also knew that the mRNA vaccine’s neutralizing antibodies were somethi

> We know our mRNA vaccines are safe and they worked great against Delta. Yes and no. We also knew that the mRNA vaccine’s neutralizing antibodies were something like 8x less effective against delta, but there was still enough left in the oomph budget to work. At least initially (at some point, your immune system wanes and that 8x less might become a bigger issue). Moderna was working on a spike-specific booster toward the original South African variant (I guess because it’s spike protein was sufficiently different to worry), but I think it died off because delta took over. https://www.nbcnews.com/science/science-news/moderna-test-booster-shot-targets-south-african-variant-rcna310 https://www.nbcnews.com/science/science-news/moderna-test-bo... My issue is that the trend was looking unfavourable, but we did nothing about it except pray.