> Since then all analysis has validated the booster strategy, even in individuals who previously had COVID. No, it hasn't. Just a week ago: https://vinayprasa

> Since then all analysis has validated the booster strategy, even in individuals who previously had COVID. No, it hasn't. Just a week ago: https://vinayprasadmdmph.substack.com/p/vaccine-effectiveness-goes-down-the https://vinayprasadmdmph.substack.com/p/vaccine-effectivenes... Vaccine efficacy for 3rd dose, out of Ontario, is somewhere in the 30-40% range. In Denmark, secondary attack rate for 3 doses is essentially equivalent to being unvaccinated. This is the latest data we have. In the UK, December 28, 2021: > efficacy of a third dose of a COVID-19 vaccine waned significantly at the 10-week mark, leaving boosted individuals at risk of infection with Omicron....In a December 23 U.K. Health Security Agency (HSA) technical briefing, vaccine efficacy against symptomatic infection generally fell to around 40% some 2.5 months after a booster dose. https://www.medpagetoday.com/special-reports/exclusives/96412 https://www.medpagetoday.com/special-reports/exclusives/9641... Also from the UK (January 6, 2022): vaccine effectiveness against symptomatic infection, 2-4 weeks after dose 3, is essentially equivalent to effectiveness after dose 2: https://twitter.com/PaulMainwood/status/1481220965539500032 https://twitter.com/PaulMainwood/status/1481220965539500032 Denmark again, January 5, 2022: > data just released from Denmark (where 85% of infections are omicron) show no effect of the booster against being infected and no difference between 2 and 3 doses against severe disease except 3 doses better against severe disease for those >70. https://twitter.com/TracyBethHoeg/status/1478853178699354112 https://twitter.com/TracyBethHoeg/status/1478853178699354112 The overall picture is of a vaccine that is temporarily elevating antibody levels, which then decline rapidly. But this isn't unexpected. It's exactly what we thought would happen. Moderna CEO, January 6, 2022: > Bancel said the efficacy of boosters will probably decline over the course of several months, similar to what happened with the first two doses. https://www.cnbc.com/2022/01/06/moderna-ceo-says-people-may-need-fourth-covid-shot-as-efficacy-of-boosters-likely-to-decline-over-time.html https://www.cnbc.com/2022/01/06/moderna-ceo-says-people-may-... ...but don't worry! Because the good news is that we have really solid data that after only two doses, even high-risk people remain well-protected against severe disease: > Among 1,228,664 persons who completed primary vaccination during December 2020–October 2021, severe COVID-19–associated outcomes (0.015%) or death (0.0033%) were rare. Risk factors for severe outcomes included age ≥65 years, immunosuppressed, and six other underlying conditions. All persons with severe outcomes had at least one risk factor; 78% of persons who died had at least four. https://www.cdc.gov/mmwr/volumes/71/wr/mm7101a4.htm https://www.cdc.gov/mmwr/volumes/71/wr/mm7101a4.htm