4 ms·

Why would fibrinolytics have any therapeutic effect? They are not anti coagulants (i.e. serine protease inhibitors), and work via an entirely different mechani

Why would fibrinolytics have any therapeutic effect? They are not anti coagulants (i.e. serine protease inhibitors), and work via an entirely different mechanism.

LinuxBender 5y ago
Absolutely not anti-coagulants. They work in conjunction with them to break up clots and absolutely have many different mechanisms. I use six of those mechanisms for controlling blood pressure. The article topic covers fibrin amyloid microclots which is precisely what many surgeons have used these enzymes for in addition to removing scar tissue from the vasculature. On a side note this is a very divided and heated topic within the different groups of heart surgeons.
- sithadmin 5y ago
  You're specifically using compounds like nattokinase to control blood pressure? Would be interested in hearing what your approach here is, or any literature you could share.
  - LinuxBender 5y ago
    You're specifically using compounds like nattokinase to control blood pressure? Correct. Here [1] is one of the studies though there are quite a few on nih.gov that vary in results and P-value. In full disclosure I use much higher FU's than what is used in their test and have been using it for a long time building up to those levels so my risks are lower. I use this in combination with vascular de-calcification methods and other molecules that break down plaques. I don't have any of them handy but you can also find some videos that talk about the different mechanisms that Natto interact with that affect BP. It is surprisingly not what one might expect. While it does bind to ACE2 that has a very insignificant role in BP. The biggest effect comes from how it changes a feedback mechanism in a peptide chain. I was taken aback when I learned how many roles peptides play in mammals well beyond tissue repair. On a fun side note Natto also has an effect on von Willebrand factor which is also plays a significant role in covid. I should of course add that I am not a doctor and this is not medical advise. Enzymes can break down scar tissue, plaques and more. These come with some risk of bleeding and stroke - one must study the risks and discuss with their doctors that will likely give them blank stares until they say "orally bioavailable tissue plasminogen activator" which is not entirely correct but it will help them understand the intent and might tickle their curiosity. [1] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066864/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066864/
    - sithadmin 5y ago
      Interesting. Seems I have a new rabbit hole to investigate. Thanks for the response.

Why would fibrinolytics have any therapeutic effect? They are not anti coagulants (i.e. serine protease inhibitors), and work via an entirely different mechanism.

LinuxBender 5y ago

Absolutely not anti-coagulants. They work in conjunction with them to break up clots and absolutely have many different mechanisms. I use six of those mechanisms for controlling blood pressure. The article topic covers fibrin amyloid microclots which is precisely what many surgeons have used these enzymes for in addition to removing scar tissue from the vasculature. On a side note this is a very divided and heated topic within the different groups of heart surgeons.

sithadmin 5y ago
You're specifically using compounds like nattokinase to control blood pressure? Would be interested in hearing what your approach here is, or any literature you could share.
- LinuxBender 5y ago
  You're specifically using compounds like nattokinase to control blood pressure? Correct. Here [1] is one of the studies though there are quite a few on nih.gov that vary in results and P-value. In full disclosure I use much higher FU's than what is used in their test and have been using it for a long time building up to those levels so my risks are lower. I use this in combination with vascular de-calcification methods and other molecules that break down plaques. I don't have any of them handy but you can also find some videos that talk about the different mechanisms that Natto interact with that affect BP. It is surprisingly not what one might expect. While it does bind to ACE2 that has a very insignificant role in BP. The biggest effect comes from how it changes a feedback mechanism in a peptide chain. I was taken aback when I learned how many roles peptides play in mammals well beyond tissue repair. On a fun side note Natto also has an effect on von Willebrand factor which is also plays a significant role in covid. I should of course add that I am not a doctor and this is not medical advise. Enzymes can break down scar tissue, plaques and more. These come with some risk of bleeding and stroke - one must study the risks and discuss with their doctors that will likely give them blank stares until they say "orally bioavailable tissue plasminogen activator" which is not entirely correct but it will help them understand the intent and might tickle their curiosity. [1] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066864/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066864/
  - sithadmin 5y ago
    Interesting. Seems I have a new rabbit hole to investigate. Thanks for the response.