6 ms·

Omicron Has Potential to Stop the Pandemic, but That's Not the End of the Story

22 points by ricc 5y ago

raxxorrax 5y ago
> Less than half of those vaccinated have received their booster shot. It will become endemic with or without a booster, it is just personal risk at this point. To be honest, currently not keen on taking it. My vaccination was just 3 month ago and I don't want to test another manufacturer. So, no thank you. Give my dose to someone in a risk group.
- swader999 5y ago
  I experienced a severe reaction (essentially long covid) to the first dose. Not taking another and it seems ridiculous to train my immune system on a non-existent alpha strain with further doses. I'll treat early with ivermectin and I use nasal spray after risky environmental exposure.
  - Tagbert 5y ago
    Why would you bother with something risky like Ivermectin, especially when it has not been shown to have any beneficial effect on COVID?
    - tinus_hn 5y ago
      So where has it been shown to be risky?
    - swader999 5y ago
      Safety profile of ivermectin is well established over decades and millions of doses. On the WHO list of essential medicines. It has a growing list of impressive rct results. The initial take down of the treatment was based on under powered trials (too low of dose, not enough doses and too late in progression). One can easily surmise it was discredited to promote more lucrative vaccines and on patent similar anti viral drugs. Just follow the money and look at who owns media, pharmaceuticals, and big tech. Gates, Fauci, black rock, vanguard, state street... I know it works from personal experience, millions of observational data points, and anecdotal reports from hundreds of trusted people.
      - boeingUH60 5y ago
        From what I know, Merck, the manufacturer of Ivermectin, discredited its use as a Covid-19 treatment [1]. If there's any one with the incentive to promote it, it's them, but they didn't. It strikes me as weird that some people still stubbornly tout the drug. 1- https://www.merck.com/news/merck-statement-on-ivermectin-use-during-the-covid-19-pandemic/ https://www.merck.com/news/merck-statement-on-ivermectin-use...
        swader999 5y ago
        They definitely did their best to discredit it. It's off patent, they have no financial incentive to promote it and huge incentive to burry it. They stand to make a lot of money off of their newer competitor to ivermectin called molnupiravir, just approved under emergency use authorisation.$700 per dose if I remember correctly vs less than a penny per dose to manufacture ivermectin.
      - thebruce87m 5y ago
        Do you have a link to these millions of data points?
        swader999 5y ago
        Sure, here you go: https://covid19criticalcare.com/ivermectin-in-covid-19/epidemiologic-analyses-on-covid19-and-ivermectin/ https://covid19criticalcare.com/ivermectin-in-covid-19/epide... They link to the source data for each region analyzed so you can check it yourself if inclined.
        thebruce87m 5y ago
        Data validity aside, not sure I like the look of the disclaimer: “Information is not intended as a replacement for diagnosis or treatment by your doctor. Nothing on this Website provides medical advice or any form of diagnosis or treatment of any kind to web users.”
- tsywke44 5y ago
  - notquitehere 5y ago
    What kind of clean room do you think your DNA originated in?
    - thatguy0900 5y ago
      I wonder what the chances that any given breath of air you take has been in a rectum before are. Should probably avoid breathing just in case
- ivraatiems 5y ago
  If you got your vaccination 3 months ago, I don't think you qualify for a booster yet anyway? Maybe in Germany, but not in the States.
  - nousermane 5y ago
    (deleted)
    - gruturo 5y ago
      > Also, you get the same vaccine as first two Not necessarily. I had (in Germany) first 2 shots with Biontech (Pfizer), and the booster with Moderna. They had both Biontech and Moderna doses available, but gave me the latter.
    - raxxorrax 5y ago
      No, I would get Comirnaty instead of Spikevax. I got Spikevax the first time around.
      - tamaharbor 5y ago
        Two more boosters then I am going rehab, I promise.
- tsol 5y ago
  You can't switch manufacturers. Once your body produces an antibody response to one vaccine, that is it's response from then on. It won't create a different response to another vaccine. Repeated 'infections' just strengthen the preexisting response
  - netizen-936824 5y ago
    Different manufacturers use different compounds at different concentrations. What do you mean "you can't switch"? Plenty of people are getting moderna boosters after the first two being pfizer
    - tsol 5y ago
      What I meant is you won't develop separate antibody responses to each individual vaccine. You can mix and match the initial vaccine and boosters, and it'll strengthen your immune response. You just can't switch and expect the same response as someone taking that particular vaccine for the first time
      - netizen-936824 5y ago
        >separate antibody responses Of course not, they use the same mRNA. There's no reason to suspect they would in the first place. The difference in response in the degree/intensity of response to the detected antigen. This is due to the concentration of mRNA in the vaccine (and therefore the concentration of antigen produced by the vaccine) Moderna creates a greater response than Pfizer due to concentration (100mcg vs 30mcg). I don't think there's a reason to believe that a moderna booster on top of a Pfizer initial vaccination would not increase the degree of response when an actual infection is detected. Immunology is not my field however so my knowledge is a bit limited.
  - GuB-42 5y ago
    Yes you can, it is possible in most country, even sometimes recommended. For now, in most of the western world, only mRNA boosters are recommended, especially if your first dose(s) are of another vaccine. Moderna and Pfizer/BioNTech shots can be mixed, Pfizer/BioNTech is recommended if you are a young man (risks of myocardite), and for others, there is a slight preference for using the other one.
ekanes 5y ago
Strange article. Endemic: (of a disease or condition) regularly found among particular people or in a certain area. Article: “There are only two paths that can get us to endemic status: mass infection, along with the illness and deaths that entails. Or mass vaccination.” It’s already endemic.
- titzer 5y ago
  Seriously. It's not like "endemic" means harmless--it has absolutely no bearing on the symptoms, severity, or survivability. The word literally just means commonplace. The term "herd immunity" fell out of fashion pretty quick, so now they are shooting for merely endemic.
  - scottiebarnes 5y ago
    It does mean exponential/rapid growth spikes are less likely, which means hospital resources are less likely to be strained, which is generally better for health workers, covid patients, and general society.
- yayachiken 5y ago
  Many of the definitions I found so far explicitly include that to reach an "endemic state", the reproduction number of a disease must be around 1. This implies that local outbreaks may still happen but will eventually burn out with no additional intervention, which characterizes the endemic state. I don't think it is fair to attack an article on semantics.

22 points by ricc 5y ago

> Less than half of those vaccinated have received their booster shot. It will become endemic with or without a booster, it is just personal risk at this point. To be honest, currently not keen on taking it. My vaccination was just 3 month ago and I don't want to test another manufacturer. So, no thank you. Give my dose to someone in a risk group.

swader999 5y ago
I experienced a severe reaction (essentially long covid) to the first dose. Not taking another and it seems ridiculous to train my immune system on a non-existent alpha strain with further doses. I'll treat early with ivermectin and I use nasal spray after risky environmental exposure.
- Tagbert 5y ago
  Why would you bother with something risky like Ivermectin, especially when it has not been shown to have any beneficial effect on COVID?
  - tinus_hn 5y ago
    So where has it been shown to be risky?
  - swader999 5y ago
    Safety profile of ivermectin is well established over decades and millions of doses. On the WHO list of essential medicines. It has a growing list of impressive rct results. The initial take down of the treatment was based on under powered trials (too low of dose, not enough doses and too late in progression). One can easily surmise it was discredited to promote more lucrative vaccines and on patent similar anti viral drugs. Just follow the money and look at who owns media, pharmaceuticals, and big tech. Gates, Fauci, black rock, vanguard, state street... I know it works from personal experience, millions of observational data points, and anecdotal reports from hundreds of trusted people.
    - boeingUH60 5y ago
      From what I know, Merck, the manufacturer of Ivermectin, discredited its use as a Covid-19 treatment [1]. If there's any one with the incentive to promote it, it's them, but they didn't. It strikes me as weird that some people still stubbornly tout the drug. 1- https://www.merck.com/news/merck-statement-on-ivermectin-use-during-the-covid-19-pandemic/ https://www.merck.com/news/merck-statement-on-ivermectin-use...
      - swader999 5y ago
        They definitely did their best to discredit it. It's off patent, they have no financial incentive to promote it and huge incentive to burry it. They stand to make a lot of money off of their newer competitor to ivermectin called molnupiravir, just approved under emergency use authorisation.$700 per dose if I remember correctly vs less than a penny per dose to manufacture ivermectin.
    - thebruce87m 5y ago
      Do you have a link to these millions of data points?
      - swader999 5y ago
        Sure, here you go: https://covid19criticalcare.com/ivermectin-in-covid-19/epidemiologic-analyses-on-covid19-and-ivermectin/ https://covid19criticalcare.com/ivermectin-in-covid-19/epide... They link to the source data for each region analyzed so you can check it yourself if inclined.
        thebruce87m 5y ago
        Data validity aside, not sure I like the look of the disclaimer: “Information is not intended as a replacement for diagnosis or treatment by your doctor. Nothing on this Website provides medical advice or any form of diagnosis or treatment of any kind to web users.”
tsywke44 5y ago
- notquitehere 5y ago
  What kind of clean room do you think your DNA originated in?
  - thatguy0900 5y ago
    I wonder what the chances that any given breath of air you take has been in a rectum before are. Should probably avoid breathing just in case
ivraatiems 5y ago
If you got your vaccination 3 months ago, I don't think you qualify for a booster yet anyway? Maybe in Germany, but not in the States.
- nousermane 5y ago
  (deleted)
  - gruturo 5y ago
    > Also, you get the same vaccine as first two Not necessarily. I had (in Germany) first 2 shots with Biontech (Pfizer), and the booster with Moderna. They had both Biontech and Moderna doses available, but gave me the latter.
  - raxxorrax 5y ago
    No, I would get Comirnaty instead of Spikevax. I got Spikevax the first time around.
    - tamaharbor 5y ago
      Two more boosters then I am going rehab, I promise.
tsol 5y ago
You can't switch manufacturers. Once your body produces an antibody response to one vaccine, that is it's response from then on. It won't create a different response to another vaccine. Repeated 'infections' just strengthen the preexisting response
- netizen-936824 5y ago
  Different manufacturers use different compounds at different concentrations. What do you mean "you can't switch"? Plenty of people are getting moderna boosters after the first two being pfizer
  - tsol 5y ago
    What I meant is you won't develop separate antibody responses to each individual vaccine. You can mix and match the initial vaccine and boosters, and it'll strengthen your immune response. You just can't switch and expect the same response as someone taking that particular vaccine for the first time
    - netizen-936824 5y ago
      >separate antibody responses Of course not, they use the same mRNA. There's no reason to suspect they would in the first place. The difference in response in the degree/intensity of response to the detected antigen. This is due to the concentration of mRNA in the vaccine (and therefore the concentration of antigen produced by the vaccine) Moderna creates a greater response than Pfizer due to concentration (100mcg vs 30mcg). I don't think there's a reason to believe that a moderna booster on top of a Pfizer initial vaccination would not increase the degree of response when an actual infection is detected. Immunology is not my field however so my knowledge is a bit limited.
- GuB-42 5y ago
  Yes you can, it is possible in most country, even sometimes recommended. For now, in most of the western world, only mRNA boosters are recommended, especially if your first dose(s) are of another vaccine. Moderna and Pfizer/BioNTech shots can be mixed, Pfizer/BioNTech is recommended if you are a young man (risks of myocardite), and for others, there is a slight preference for using the other one.

ekanes 5y ago

Strange article. Endemic: (of a disease or condition) regularly found among particular people or in a certain area. Article: “There are only two paths that can get us to endemic status: mass infection, along with the illness and deaths that entails. Or mass vaccination.” It’s already endemic.

titzer 5y ago
Seriously. It's not like "endemic" means harmless--it has absolutely no bearing on the symptoms, severity, or survivability. The word literally just means commonplace. The term "herd immunity" fell out of fashion pretty quick, so now they are shooting for merely endemic.
- scottiebarnes 5y ago
  It does mean exponential/rapid growth spikes are less likely, which means hospital resources are less likely to be strained, which is generally better for health workers, covid patients, and general society.
yayachiken 5y ago
Many of the definitions I found so far explicitly include that to reach an "endemic state", the reproduction number of a disease must be around 1. This implies that local outbreaks may still happen but will eventually burn out with no additional intervention, which characterizes the endemic state. I don't think it is fair to attack an article on semantics.