5 ms·

Also you could really only develop a strain that was more infectious/less deadly in mice, using mice. Once you jump it back to humans it's a new roll of the di

Also you could really only develop a strain that was more infectious/less deadly in mice, using mice. Once you jump it back to humans it's a new roll of the dice on whether it's more or less deadly and infectious.

dr_dshiv 5y ago
I generally agree. But it seems possible to know a priori that it wouldn't adversely affect the lungs, which is the primary cause of death/damage.
- p_l 5y ago
  Except lungs are, arguably, a minor (just most visible) issue with COVID. We're going to deal with long history of disablement caused by how COVID attacks neural tissue, for example, something I think might be more disastrous long term (1918 flu was similar, with some historic effects like Aktion T-4)
  - dr_dshiv 5y ago
    Got a cite to share?
    - jwozn 5y ago
      There's this: https://www.researchsquare.com/article/rs-1139035/v1 https://www.researchsquare.com/article/rs-1139035/v1 But, also this: https://twitter.com/andrew_croxford/status/1476209804666601472 https://twitter.com/andrew_croxford/status/14762098046666014...
      - dr_dshiv 5y ago
        Your cite says this: "Despite extensive distribution of SARS-CoV-2 in the body, we observed a paucity of inflammation or direct viral cytopathology outside of the lungs." Ah, and I see the tweet is trying to dispel fear that was worked up around this. Got it.
  - nradov 5y ago
    You haven't provided any evidence of a link between the 1918 flu and the Nazi Aktion T-4 mass murder program.
    - p_l 5y ago
      Essentially, a significant portion of "invalids" in Germany that Nazi targeted first were people impacted by 1918 flu, specifically those who were exposed to it in prenatal stage. This contributed towards the Aktion T-4 program, and one of the common long term effects of the flu was among the targeted diseases, outside of just increased disability counts in German population due to 1918 flu. Reasonable starting point for looking further: https://twitter.com/pookleblinky/status/1332873432468492288 https://twitter.com/pookleblinky/status/1332873432468492288

dr_dshiv 5y ago

I generally agree. But it seems possible to know a priori that it wouldn't adversely affect the lungs, which is the primary cause of death/damage.

p_l 5y ago
Except lungs are, arguably, a minor (just most visible) issue with COVID. We're going to deal with long history of disablement caused by how COVID attacks neural tissue, for example, something I think might be more disastrous long term (1918 flu was similar, with some historic effects like Aktion T-4)
- dr_dshiv 5y ago
  Got a cite to share?
  - jwozn 5y ago
    There's this: https://www.researchsquare.com/article/rs-1139035/v1 https://www.researchsquare.com/article/rs-1139035/v1 But, also this: https://twitter.com/andrew_croxford/status/1476209804666601472 https://twitter.com/andrew_croxford/status/14762098046666014...
    - dr_dshiv 5y ago
      Your cite says this: "Despite extensive distribution of SARS-CoV-2 in the body, we observed a paucity of inflammation or direct viral cytopathology outside of the lungs." Ah, and I see the tweet is trying to dispel fear that was worked up around this. Got it.
- nradov 5y ago
  You haven't provided any evidence of a link between the 1918 flu and the Nazi Aktion T-4 mass murder program.
  - p_l 5y ago
    Essentially, a significant portion of "invalids" in Germany that Nazi targeted first were people impacted by 1918 flu, specifically those who were exposed to it in prenatal stage. This contributed towards the Aktion T-4 program, and one of the common long term effects of the flu was among the targeted diseases, outside of just increased disability counts in German population due to 1918 flu. Reasonable starting point for looking further: https://twitter.com/pookleblinky/status/1332873432468492288 https://twitter.com/pookleblinky/status/1332873432468492288