3 ms·

I too desperately want a sterilizing vaccine. Given the existence of influenza and the common cold (a bunch of rhino and corona viruses), this seems unlikely un

• eli_gottlieb 5y ago
  If it seems unlikely, then someone should explain why it works in a mouse model but not in the real world. If the virus mutates too quickly for a full sterilizing vaccine, then nonetheless, any vaccine that reduces transmission is helpful. If the virus mutates too quickly period, all the more reason for variant-specific boosters, targeted to the strains circulating, just like the yearly flu shot.
  • bigbillheck 5y ago
    > someone should explain why it works in a mouse model but not in the real world. As the saying goes, 'mice lie and monkeys exaggerate'.
  • disgruntledphd2 5y ago
    The current vaccines do, in fact, reduce transmission. This efficacy drops over time, but it definitely exists.