4 ms·
My real skepticism, having been vaccinated and boosted, is that institutions like the CDC, FDA, and Pfizer are just being lazy foot-draggers about bringing out
by eli_gottlieb 5y ago
My real skepticism, having been vaccinated and boosted, is that institutions like the CDC, FDA, and Pfizer are just being lazy foot-draggers about bringing out vaccines updated for specific variants.
And whatever happened to the project of vaccines that provide full, sterilizing immunity? Last publication I can find is for a study in freaking mice[1]. Is there no imperative to actually provide sterilizing immunity at "warp speed", because society can just shove non-sterilizing vaccines into people and save on ICU beds?
[1] -- https://www.cell.com/iscience/fulltext/S2589-0042(21)01005-1 https://www.cell.com/iscience/fulltext/S2589-0042(21)01005-1
- disgruntledphd2 5y agoI too desperately want a sterilizing vaccine. Given the existence of influenza and the common cold (a bunch of rhino and corona viruses), this seems unlikely unfortunately.
- eli_gottlieb 5y agoIf it seems unlikely, then someone should explain why it works in a mouse model but not in the real world. If the virus mutates too quickly for a full sterilizing vaccine, then nonetheless, any vaccine that reduces transmission is helpful. If the virus mutates too quickly period, all the more reason for variant-specific boosters, targeted to the strains circulating, just like the yearly flu shot.
- bigbillheck 5y ago> someone should explain why it works in a mouse model but not in the real world. As the saying goes, 'mice lie and monkeys exaggerate'.
- disgruntledphd2 5y agoThe current vaccines do, in fact, reduce transmission. This efficacy drops over time, but it definitely exists.