4 ms·

Fluvoxamine is the new off-label thing, combo sigma-1 and "ASM Functional inhibitor" https://c19fluvoxamine.com/ https://c19fluvoxamine.com/ But this time the

by ck2 5y ago

Fluvoxamine is the new off-label thing, combo sigma-1 and "ASM Functional inhibitor" https://c19fluvoxamine.com/ https://c19fluvoxamine.com/ But this time the science is a bit more solid because it works similar to the pfizer antiviral pill. The problem is SSRIs are not something to be taken casually. https://www.medrxiv.org/content/10.1101/2021.12.17.21268008 https://www.medrxiv.org/content/10.1101/2021.12.17.21268008 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2786140 https://jamanetwork.com/journals/jamanetworkopen/fullarticle... https://www.nature.com/articles/s41380-021-01309-5 https://www.nature.com/articles/s41380-021-01309-5

spurgu 5y ago
A Covid treatment with happiness as a side effect? Sign me up! ;) Is there a problem with taking SSRI's for 10 days though?
- ck2 5y ago
  It's a misunderstanding SSRIs "make you happy". They are powerful manipulators of brain (and body) chemistry. And yes, you are right to suspect taking SSRI for 10 days is a problem, most SSRI have serious withdrawal symptoms too and interact with common things like caffeine very badly. But that pfizer pill is months away from significant quantities which is way too late for omicron and nothing else works on it (like MABs) so doctors have a big problem with no tools in the toolbox.
  - spurgu 5y ago
    Ok, I don't know that much about SSRI's but I have a hard time believing that withdrawal symptoms (after 10 days of use) would be worse than a Covid case warranting treatment (= a serious one). MABs not working on Omicron was new to me. Is that based on the vaccine's (in)efficacy against it?
    - spurgu 5y ago
      > MABs not working on Omicron was new to me. Is that based on the vaccine's (in)efficacy against it? To answer my own question, no: > But a slew of publications posted on preprint servers report laboratory evidence that Omicron is totally or partially resistant to all currently available treatments based on these monoclonal antibodies. https://www.nature.com/articles/d41586-021-03829-0 https://www.nature.com/articles/d41586-021-03829-0
nradov 5y ago
Taking fluvoxamine or other SSRIs for a few days to treat an acute condition is highly unlikely to cause serious negative side effects. The real problems with SSRIs only appear after weeks of chronic use. Anecdotally I've heard several physicians report good results with fluvoxamine. It appears to be well tolerated for most patients.

by ck2 5y ago

spurgu 5y ago

A Covid treatment with happiness as a side effect? Sign me up! ;) Is there a problem with taking SSRI's for 10 days though?

ck2 5y ago
It's a misunderstanding SSRIs "make you happy". They are powerful manipulators of brain (and body) chemistry. And yes, you are right to suspect taking SSRI for 10 days is a problem, most SSRI have serious withdrawal symptoms too and interact with common things like caffeine very badly. But that pfizer pill is months away from significant quantities which is way too late for omicron and nothing else works on it (like MABs) so doctors have a big problem with no tools in the toolbox.
- spurgu 5y ago
  Ok, I don't know that much about SSRI's but I have a hard time believing that withdrawal symptoms (after 10 days of use) would be worse than a Covid case warranting treatment (= a serious one). MABs not working on Omicron was new to me. Is that based on the vaccine's (in)efficacy against it?
  - spurgu 5y ago
    > MABs not working on Omicron was new to me. Is that based on the vaccine's (in)efficacy against it? To answer my own question, no: > But a slew of publications posted on preprint servers report laboratory evidence that Omicron is totally or partially resistant to all currently available treatments based on these monoclonal antibodies. https://www.nature.com/articles/d41586-021-03829-0 https://www.nature.com/articles/d41586-021-03829-0

nradov 5y ago

Taking fluvoxamine or other SSRIs for a few days to treat an acute condition is highly unlikely to cause serious negative side effects. The real problems with SSRIs only appear after weeks of chronic use. Anecdotally I've heard several physicians report good results with fluvoxamine. It appears to be well tolerated for most patients.