I’m talking about irreversible physiological changes caused by getting fat that don’t reverse after you lose weight. This is what makes keeping weight off after

I’m talking about irreversible physiological changes caused by getting fat that don’t reverse after you lose weight. This is what makes keeping weight off after losing a bunch harder than maintaining the same weight if you’ve never been fat to start with. Things like damage in the hippocampus preventing normal leptin signaling. Once you’ve gotten fat, you’re pretty much fucked for life, even if you reverse the behaviors that got you there. https://www.stephanguyenet.com/thehungrybrain/ https://www.stephanguyenet.com/thehungrybrain/