3 ms·
They're saying that it had low effect on immediate neutralization of the virus (sterilizing immunity). You're still well-protected against severe disease. Far
by timr 5y ago
They're saying that it had low effect on immediate neutralization of the virus (sterilizing immunity). You're still well-protected against severe disease.
Far too much fear-mongering has happened based on confusion about what different studies are measuring. Measures of "neutralization titer" are pretty much pointless, outside of a lab -- they're a model for immunity with no demonstrated relevance to real-world outcomes.
Studies involving "symptomatic disease" are trying to measure the chance you might get any symptoms at all -- a very low bar. Even the sniffles count here. This is where most of the pro-booster studies have focused, and it's a pretty lame endpoint, unless you continue to harbor the delusion that "zero covid" is a thing that is possible (it is not).
Basically, if you get infected after two doses, you might get cold-like symptoms, unless you're either severely immunocompromised (e.g. on immune suppressants, AIDS, in the middle of a bone marrow transplant, etc.) or so old that your immune system is failing anyway.
- alex_duf 5y agoThanks, I hadn't made that distinction between immediate and long term protection. The immune system is pretty complicated.