8 ms·
It's exactly what I'm asking, what is the status of our current metabolic pathway simulations for example ? how much about protein denaturation do we need to kn
by up6w6 5y ago
It's exactly what I'm asking, what is the status of our current metabolic pathway simulations for example ? how much about protein denaturation do we need to know before protein structure prediction is useful ?
- pfisherman 5y ago> how much about protein denaturation do we need to know before protein structure prediction is useful ? Denaturation is not all that significant. Physiological conditions (i.e. pH, temperature, etc) tend to be maintained by homeostasis. Protein structure prediction is already incredibly useful. > what is the status of our current metabolic pathway simulations for example ? IMO we do not have the data to build useful metabolic pathway simulations. To do a good simulation you need to know (1) the proteins and metabolites involved, (2) their functions and key biophysical properties (ex. Km), (3) feedback / control elements. For most pathways we do not have (1). The data for (2) are mostly nonexistent, buried in literature, and / or unreliable. Same with (3).