4 ms·
In mice? Also, the lab animal telomere issue has corrupted almost all animal studies in the last 50 years, but there doesn't seem to be any effort to correct c
by robbedpeter 5y ago
In mice?
Also, the lab animal telomere issue has corrupted almost all animal studies in the last 50 years, but there doesn't seem to be any effort to correct course, or even to acknowledge the problem.
- ramraj07 5y agoWhat lab animal telomere issue? Never heard of that in my decade of working in a lab.
- hall0ween 5y agoAlso curious to know.
- Semaphor 5y agoThis seems relevant both for the links and the rebuttal (?): https://biology.stackexchange.com/questions/90609/why-might-long-telomeres-be-selected-for-in-laboratory-mice https://biology.stackexchange.com/questions/90609/why-might-...
- alextheparrot 5y agoProbably regurgitating it from the Weinstein stuff. https://uncancelclub.com/bret-weinstein-1/ https://uncancelclub.com/bret-weinstein-1/
- ashwal 5y agoThey're probably referring to: https://pubmed.ncbi.nlm.nih.gov/11909679/ https://pubmed.ncbi.nlm.nih.gov/11909679/ I think this is one symptom of a much greater issue: the inbred mice strains we use are disastrously weird (arising from the initial population artificially bred to make research easier). For the sake of controlling for genetics, we've chosen to make lab research translation drastically less effective.
- KenoFischer 5y agoI'm assuming OP is referring to this: https://oncobites.blog/2020/07/29/modeling-aging-and-cancer-are-lab-mice-different-from-their-wild-cousins/ https://oncobites.blog/2020/07/29/modeling-aging-and-cancer-...
- robbedpeter 5y agohttps://www.nobelprize.org/prizes/medicine/2009/illustrated-information/#:~:text=The%20Nobel%20Assembly%20at%20Karolinska,telomeres%20and%20the%20enzyme%20telomerase https://www.nobelprize.org/prizes/medicine/2009/illustrated-... 2009 Nobel prize given for this work. Lab animals, due to the way they are bred, are essentially susceptible to cancer and health issues not seen in normal wildtype populations. Shortened telomeres are the primary danger, increasing mutation rate and cell senescence. Essentially, all data involving the expectation of normal cellular behavior is subject to question - signaling from lab animals is corrupted.
- pazimzadeh 5y agoDo you have a source because as I understand it the length of the telomeres is reset each generation and so generally not transmissible to the next generation. Apparently leukocyte telomere length is heritable though, is that what you are talking about?
- robbedpeter 5y agohttps://pubmed.ncbi.nlm.nih.gov/11909679/ https://pubmed.ncbi.nlm.nih.gov/11909679/ https://www.gwern.net/docs/longevity/2002-weinstein.pdf https://www.gwern.net/docs/longevity/2002-weinstein.pdf
- ramraj07 5y agoWhat exactly are you interpreting out of this paper now ? How does this invalidate cancer studies in mice? Most cancer studies in mice are xenografts of human cancer cells so any relevance of mice telomeres is completely lost anyway. Also this obsession with telomeres being the fundamental key for all our biological problems seems so conspiratorial. Like you think our cells which do unimaginable things can't keep their DNA ends frothy? Like that's what is gonna spell their doom? Or you consider telomeres are just a symptom of a cells longevity decided by other factors ?
- AceJohnny2 5y agoThe Nobel prize is about discovery of the telomeres, not about anything about lab populations.