My only experience with Mister is playing SNES games with the device my brother set up on a CRT tv. Playing an SNES game is just a matter of choosing the SNES

My only experience with Mister is playing SNES games with the device my brother set up on a CRT tv. Playing an SNES game is just a matter of choosing the SNES core, picking the game rom from the default directory, and learning the hot key combination on the controller to go to the save menu to save your in game save file to the sd card. For this use case it's easier than Retroarch- you don't need to fiddle with resolutions since everything outputs natively to the CRT and you don't need to fiddle with cores since only 1 core exists per system. Maybe there's more complex features that are harder to use, but as a replacement for a super nintendo I find it to be dead simple to use once setup.