6 ms·

Probiotic that produces lactase enzymes directly in gut

38 points by mataug 5y ago

mcc1ane 5y ago
https://arstechnica.com/science/2018/09/probiotics-if-you-dont-just-just-poop-them-out-they-may-muck-up-your-guts/ https://arstechnica.com/science/2018/09/probiotics-if-you-do...
mataug 5y ago
There's some research to suggest that certain probiotic supplements could help with lactose intolerance, but this still seems like there's a need for more research. Curious to hear thoughts / experiences with bactose ? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284493/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284493/
- Bactories 5y ago
  Hi Mataug, Thanks for posting, we are super small so we notice these things, haha. LA does produce lactase naturally, ours produces about 60% more than other LA strains, and also adheres to the intestinal lining really well, which is why it can last so long. We have a moneyback guarantee, so if you want to order it on subscription and use the discount code on the site, you can get it pretty cheap, then also if do not like it send us an email to get a refund. Let me know any other questions or requests.
Kaibeezy 5y ago
$40 a month, and you still have to take 3 a day for a week. Nah. I’ve been dealing with carrying pills around for decades, it’s not that onerous. The price of lactase has come down too, used to be like $0.50 per pill, but I still don’t think I ever took 80 of them a month. Plus it makes me more mindful of what I’m eating generally, and also encourages me to try and even make new stuff, especially drinks - kombucha, kvass, kefir water, oat milk, homemade syrups for soda, etc.
- ihumanable 5y ago
  Yea, you can get 180 pills from CostCo for $18 ($0.10 / pill). These seem wildly over priced considering that it defines "long-lasting" as 1 month, meh. For a year this is $40 * 12 = $480. Or I could get 180 pills from CostCo (and you could probably source these cheaper) for $18, even if I ate dairy at every meal 365 * 3 = 1095, I would only need 1095 / 180 = 6.08 (round up to 7) boxes of Fast-Acting Lactase which is only 7 * $18 = $126. This is 4 times the price and for 1 week each month I need to remember to take 3 pills a day. The value prop just doesn't add up, it's not hard to source or have lactase pills on hand. https://www.costco.com/kirkland-signature-fast-acting-lactase%2C-180-caplets.product.100096414.html https://www.costco.com/kirkland-signature-fast-acting-lactas...
  - Bactories 5y ago
    Check out my comment above, but I just wanted to say I am a costco whore, everything from the snacks in my pantry and freezer, to my tv to furniture is costco derived. If you are in Austin, we should go hit up a costco together, I am serius.
  - Kaibeezy 5y ago
    > defines “long-lasting” as 1 month Where’s this? You take a pill with each serving of dairy. I usually carry a strip of 3 or 6 individually packaged pills if I’m out for the day. Each pouch has an expiration date on it, and that’s at least a couple of years, so I leave stashes in the car, camera bag, friends’ houses, wherever. Even taking 3 or 4 on some days, you’re still right, the cost isn’t much of an issue.
    - ihumanable 5y ago
      Apologies if my original comment wasn't clear. Fast-acting Lactase is something you take with every serving of dairy. The Bactose product that this post is about says the following "Long lasting effects Bactose™ will continue to thrive digesting lactose for the whole month, individual results may vary." I was trying to say that the Bactose product's "long-lasting" claim falls a bit flat when you realize it only lasts a month. If I could take some pills for a week and then be set for 6-months or a year, yea, I might drop $40 on it.
modeless 5y ago
The lorem ipsum on the "journal" page does not inspire confidence. But I definitely believe that the idea is feasible. There's that guy who genetically engineered himself to produce lactose[1] and it worked, and this seems like a less risky way to do it. I'd love for a real product along these lines to come out. Would it even be legal to sell it though? [1] https://www.youtube.com/watch?v=J3FcbFqSoQY https://www.youtube.com/watch?v=J3FcbFqSoQY
- Bactories 5y ago
  We will be releasing our GMO version in 2022. I anticipate its efficacy to be incredible. We will be performing quite a few safety studies ahead of this release. The site is brand new, please give it time, my cofounder has remade the site 3 times in the past 7 months, he promises this is the last time though (for now haha).
  - philipkimmey 5y ago
    I would suggest a deeper scan of the site for copy editing - there’s at least one mention of “diary” when “dairy” is clearly intended. (I’d probably wait for more usage and supporting evidence before trying something like this, but the prospect of no-regrets dairy consumption is very appealing.)
deleted 5y ago
[deleted]
- WithinReason 5y ago
  It's automated
otterley 5y ago
You can find Lactobacillus Acidophilus probiotics at any health food store, or on Amazon. This is hardly novel - and this one appears to be over 23x the price per pill as the existing alternatives! ($1.90/ea vs $0.08/ea)
- tyingq 5y ago
  Yep. They scale the "active ingredient" image down, but here's the larger version: https://cdn.shopify.com/s/files/1/0590/6667/9502/products/box-rendering-567-1-1024x1024_3000x.png https://cdn.shopify.com/s/files/1/0590/6667/9502/products/bo...
  - Morfeo 5y ago
    Check this out, hope it can help you: Easily add highly profitable products to your Shopify store. The new dropshipping tool from lets you add trending products to your Shopify store in minutes. It's the simplest and smartest way to dropship. https://rebrand.ly/h5v3qsw https://rebrand.ly/h5v3qsw I also leave you this free guide, it helped me a lot: https://rebrand.ly/x0qwcbv https://rebrand.ly/x0qwcbv
- pazimzadeh 5y ago
  They claim to have a specific strain which produces lots of lactase, which is possible. I agree with you on principle though.
  - otterley 5y ago
    The supplements market is full of shysters and charlatans. If they had the actual data to prove it, they would have published it.
    - antishortstocks 5y ago
      I took Bactose after seeing an IG ad, I took it for 7 days, after I could literally have any dairy I want for about 4 weeks which fell short of their claim of months. I contacted them and they explained it's not your average L.Acidophilus it's a super strain that produces an abundance of lactase enzymes in the gut. The problem with most probiotics that is that it's a placebo effect, you legit cannot effect diarrhea and gas with a placebo, either it works or it doesn't, for me it worked and it was glorious....
pazimzadeh 5y ago
Since the active ingredient here is 5 billion colony forming units of Lactobacillus acidophilus, I wonder how this differs from getting from another source i.e. yoghurt > Through our research, we discovered a novel strain of lactobacillus acidophilus bacteria that will colonize the mammalian intestine and actively produce an excess volume of lactase enzymes It would be nice if there was a paper demonstrating the claims about this specific strain of L. acidophilus
- Bactories 5y ago
  Hi my name is Mike, I am one of the cofounders of Bactories, the creators of Bactose. There are only two things truly unique about our strain. 1) It produces about 60% more lactase enzymes than other lactobacillus strains we tested 2) the really key thing, it is evolved to adhere to the mammalian intestinal lining, this is the crucial point of 1 week of taking pills being able to provide 1 or more months of continued efficacy. If you took other LA strains their effects would wear off quickly, why you not get continued lactase tolerance with them. Let me know any other questions.
  - text70 5y ago
    Have the strains been engineered with a BAC or through CRISPR-type editing or something with Cre-recombinase to get over-expression of lactase? Any out-patient nutritional studies showing GI intestinal biome data with positive growth conclusions?
prirun 5y ago
I had diarrhea problems for a few years that no doctor diagnosed. I found on my own that taking a probiotic twice a day completely fixed it, within a few days. The probiotic (Amazon's most popular) was around $13 for 30 pills, so it was going to be $25/mo. That worked, but instead of spending $25/mo, I started making yogurt and using a couple of opened probiotic capsules as the starter. I'm also recently lactose intolerant, so I let the yogurt ferment 24 hours to ensure all the milk sugar is consumed by the bacteria. I strain it to make Greek yogurt, which to me isn't as tart and tastes more like sour cream. 2 probiotic capsules and a half gallon of milk costs less than $4 for 2 quarts of yogurt. I only have to eat a spoonful in the morning before breakfast. Works great! If these lactase-producing probiotics actually do work and are safe, making yogurt with them might be an easy and cheap way to get the same benefits. Edit: corrected the price to $25/mo

38 points by mataug 5y ago

https://arstechnica.com/science/2018/09/probiotics-if-you-dont-just-just-poop-them-out-they-may-muck-up-your-guts/ https://arstechnica.com/science/2018/09/probiotics-if-you-do...

mataug 5y ago

There's some research to suggest that certain probiotic supplements could help with lactose intolerance, but this still seems like there's a need for more research. Curious to hear thoughts / experiences with bactose ? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284493/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284493/

Bactories 5y ago
Hi Mataug, Thanks for posting, we are super small so we notice these things, haha. LA does produce lactase naturally, ours produces about 60% more than other LA strains, and also adheres to the intestinal lining really well, which is why it can last so long. We have a moneyback guarantee, so if you want to order it on subscription and use the discount code on the site, you can get it pretty cheap, then also if do not like it send us an email to get a refund. Let me know any other questions or requests.

Kaibeezy 5y ago

$40 a month, and you still have to take 3 a day for a week. Nah. I’ve been dealing with carrying pills around for decades, it’s not that onerous. The price of lactase has come down too, used to be like $0.50 per pill, but I still don’t think I ever took 80 of them a month. Plus it makes me more mindful of what I’m eating generally, and also encourages me to try and even make new stuff, especially drinks - kombucha, kvass, kefir water, oat milk, homemade syrups for soda, etc.

ihumanable 5y ago
Yea, you can get 180 pills from CostCo for $18 ($0.10 / pill). These seem wildly over priced considering that it defines "long-lasting" as 1 month, meh. For a year this is $40 * 12 = $480. Or I could get 180 pills from CostCo (and you could probably source these cheaper) for $18, even if I ate dairy at every meal 365 * 3 = 1095, I would only need 1095 / 180 = 6.08 (round up to 7) boxes of Fast-Acting Lactase which is only 7 * $18 = $126. This is 4 times the price and for 1 week each month I need to remember to take 3 pills a day. The value prop just doesn't add up, it's not hard to source or have lactase pills on hand. https://www.costco.com/kirkland-signature-fast-acting-lactase%2C-180-caplets.product.100096414.html https://www.costco.com/kirkland-signature-fast-acting-lactas...
- Bactories 5y ago
  Check out my comment above, but I just wanted to say I am a costco whore, everything from the snacks in my pantry and freezer, to my tv to furniture is costco derived. If you are in Austin, we should go hit up a costco together, I am serius.
- Kaibeezy 5y ago
  > defines “long-lasting” as 1 month Where’s this? You take a pill with each serving of dairy. I usually carry a strip of 3 or 6 individually packaged pills if I’m out for the day. Each pouch has an expiration date on it, and that’s at least a couple of years, so I leave stashes in the car, camera bag, friends’ houses, wherever. Even taking 3 or 4 on some days, you’re still right, the cost isn’t much of an issue.
  - ihumanable 5y ago
    Apologies if my original comment wasn't clear. Fast-acting Lactase is something you take with every serving of dairy. The Bactose product that this post is about says the following "Long lasting effects Bactose™ will continue to thrive digesting lactose for the whole month, individual results may vary." I was trying to say that the Bactose product's "long-lasting" claim falls a bit flat when you realize it only lasts a month. If I could take some pills for a week and then be set for 6-months or a year, yea, I might drop $40 on it.

modeless 5y ago

The lorem ipsum on the "journal" page does not inspire confidence. But I definitely believe that the idea is feasible. There's that guy who genetically engineered himself to produce lactose[1] and it worked, and this seems like a less risky way to do it. I'd love for a real product along these lines to come out. Would it even be legal to sell it though? [1] https://www.youtube.com/watch?v=J3FcbFqSoQY https://www.youtube.com/watch?v=J3FcbFqSoQY

Bactories 5y ago
We will be releasing our GMO version in 2022. I anticipate its efficacy to be incredible. We will be performing quite a few safety studies ahead of this release. The site is brand new, please give it time, my cofounder has remade the site 3 times in the past 7 months, he promises this is the last time though (for now haha).
- philipkimmey 5y ago
  I would suggest a deeper scan of the site for copy editing - there’s at least one mention of “diary” when “dairy” is clearly intended. (I’d probably wait for more usage and supporting evidence before trying something like this, but the prospect of no-regrets dairy consumption is very appealing.)

deleted 5y ago

[deleted]

WithinReason 5y ago
It's automated

otterley 5y ago

You can find Lactobacillus Acidophilus probiotics at any health food store, or on Amazon. This is hardly novel - and this one appears to be over 23x the price per pill as the existing alternatives! ($1.90/ea vs $0.08/ea)

tyingq 5y ago
Yep. They scale the "active ingredient" image down, but here's the larger version: https://cdn.shopify.com/s/files/1/0590/6667/9502/products/box-rendering-567-1-1024x1024_3000x.png https://cdn.shopify.com/s/files/1/0590/6667/9502/products/bo...
- Morfeo 5y ago
  Check this out, hope it can help you: Easily add highly profitable products to your Shopify store. The new dropshipping tool from lets you add trending products to your Shopify store in minutes. It's the simplest and smartest way to dropship. https://rebrand.ly/h5v3qsw https://rebrand.ly/h5v3qsw I also leave you this free guide, it helped me a lot: https://rebrand.ly/x0qwcbv https://rebrand.ly/x0qwcbv
pazimzadeh 5y ago
They claim to have a specific strain which produces lots of lactase, which is possible. I agree with you on principle though.
- otterley 5y ago
  The supplements market is full of shysters and charlatans. If they had the actual data to prove it, they would have published it.
  - antishortstocks 5y ago
    I took Bactose after seeing an IG ad, I took it for 7 days, after I could literally have any dairy I want for about 4 weeks which fell short of their claim of months. I contacted them and they explained it's not your average L.Acidophilus it's a super strain that produces an abundance of lactase enzymes in the gut. The problem with most probiotics that is that it's a placebo effect, you legit cannot effect diarrhea and gas with a placebo, either it works or it doesn't, for me it worked and it was glorious....

pazimzadeh 5y ago

Since the active ingredient here is 5 billion colony forming units of Lactobacillus acidophilus, I wonder how this differs from getting from another source i.e. yoghurt > Through our research, we discovered a novel strain of lactobacillus acidophilus bacteria that will colonize the mammalian intestine and actively produce an excess volume of lactase enzymes It would be nice if there was a paper demonstrating the claims about this specific strain of L. acidophilus

Bactories 5y ago
Hi my name is Mike, I am one of the cofounders of Bactories, the creators of Bactose. There are only two things truly unique about our strain. 1) It produces about 60% more lactase enzymes than other lactobacillus strains we tested 2) the really key thing, it is evolved to adhere to the mammalian intestinal lining, this is the crucial point of 1 week of taking pills being able to provide 1 or more months of continued efficacy. If you took other LA strains their effects would wear off quickly, why you not get continued lactase tolerance with them. Let me know any other questions.
- text70 5y ago
  Have the strains been engineered with a BAC or through CRISPR-type editing or something with Cre-recombinase to get over-expression of lactase? Any out-patient nutritional studies showing GI intestinal biome data with positive growth conclusions?

prirun 5y ago

I had diarrhea problems for a few years that no doctor diagnosed. I found on my own that taking a probiotic twice a day completely fixed it, within a few days. The probiotic (Amazon's most popular) was around $13 for 30 pills, so it was going to be $25/mo. That worked, but instead of spending $25/mo, I started making yogurt and using a couple of opened probiotic capsules as the starter. I'm also recently lactose intolerant, so I let the yogurt ferment 24 hours to ensure all the milk sugar is consumed by the bacteria. I strain it to make Greek yogurt, which to me isn't as tart and tastes more like sour cream. 2 probiotic capsules and a half gallon of milk costs less than $4 for 2 quarts of yogurt. I only have to eat a spoonful in the morning before breakfast. Works great! If these lactase-producing probiotics actually do work and are safe, making yogurt with them might be an easy and cheap way to get the same benefits. Edit: corrected the price to $25/mo