I'd say fusion is a sleeper. You still have that stupid "30 years away and always will be" meme but there is real progress being made. Fusion would completely c

I'd say fusion is a sleeper. You still have that stupid "30 years away and always will be" meme but there is real progress being made. Fusion would completely change the world, though not overnight because it would take another decade or so before it would advance enough to be cost competitive. I'm semi-optimistic about space flight and longevity. I think Starship will fly, but I wouldn't be surprised if some of its most ambitious specs get dialed back a bit. I'll be somewhat (but not totally) surprised if the "chopsticks" idea works. We will probably see aging-reversal to some limited extent within 10-20 years, but the effect will probably be more to extend "health span" than add that much to life span. (I'll take it.) I'll add one not on the list: the use of deep learning to discover theories in areas like physics and math that have not occurred to humans and maybe are not capable of being found by ordinary human cognition. Wildcard, but plausible: detection of a strong extrasolar biosphere candidate using JWST or another next-generation telescope. Detection would be based on albedo absorption spectra, so we wouldn't know for sure. Talk of an interstellar fly-by probe would start pretty quickly. I wouldn't list sub-5nm as "far out." We will almost definitely get sub-5nm. AFAIK 3nm is in the pipeline. Sub-1nm is "far out" and may or may not happen.