Age of population is a huge factor that must be included but I seldom see it mentioned. Another one we don’t even understand at all yet is genetic makeup of th

Age of population is a huge factor that must be included but I seldom see it mentioned. Another one we don’t even understand at all yet is genetic makeup of the population. We know that with other diseases there are genetic markers that increase of decrease susceptibility. There probably are here too but we don’t know what they are. Differences in distribution of those markers could totally confound studies. The best comparisons right now are going to be within more genetically and demographically similar populations. Here in Ohio we have seen that the vaccine is over 90% effective at preventing severe COVID and death but far less effective at simply stopping transmission. (Ohio has used the mRNA Pfizer/Moderna one almost exclusively.) But we already know it does not sterilize. Not sure about masks and lockdowns. Have to look that up. There are even more confounders there like what masks are being used (N95 vs KN95 vs thin cloth junk) and uneven compliance that nobody is able to track.