4 ms·
Wow I didn't realize that about the dose difference, I wondered why they gave us a half dose for our booster
by brundolf 5y ago
Wow I didn't realize that about the dose difference, I wondered why they gave us a half dose for our booster
- Scoundreller 5y agoWhat’s interesting is that in the initial trials, moderna tested 50, 100 and 250mcg in humans and ultimately decided on 100mcg as the sweet spot. https://www.nih.gov/news-events/news-releases/nih-clinical-trial-evaluating-moderna-covid-19-variant-vaccine-begins https://www.nih.gov/news-events/news-releases/nih-clinical-t... Meanwhile pfizer tested 10, 30 and 100 and ultimately settled on 30mcg as their sweet spot. https://www.nature.com/articles/s41586-020-2639-4 https://www.nature.com/articles/s41586-020-2639-4 Was this due to differences in the vaccine itself, different study environments, or different tolerances for the balance between side effects and effectiveness?