3 ms·

Not really a surprise, moderna has a much higher dose, mcg for mcg. 100 vs 30. At least where I am, booster doses using moderna are recommended at half doses (

Not really a surprise, moderna has a much higher dose, mcg for mcg. 100 vs 30. At least where I am, booster doses using moderna are recommended at half doses (50mcg). They both use the same spike protein sequence. No idea how the excipients differ between the two, but neither has adjuvants.

brundolf 5y ago
Wow I didn't realize that about the dose difference, I wondered why they gave us a half dose for our booster
- Scoundreller 5y ago
  What’s interesting is that in the initial trials, moderna tested 50, 100 and 250mcg in humans and ultimately decided on 100mcg as the sweet spot. https://www.nih.gov/news-events/news-releases/nih-clinical-trial-evaluating-moderna-covid-19-variant-vaccine-begins https://www.nih.gov/news-events/news-releases/nih-clinical-t... Meanwhile pfizer tested 10, 30 and 100 and ultimately settled on 30mcg as their sweet spot. https://www.nature.com/articles/s41586-020-2639-4 https://www.nature.com/articles/s41586-020-2639-4 Was this due to differences in the vaccine itself, different study environments, or different tolerances for the balance between side effects and effectiveness?
staticassertion 5y ago
It's more than 'not really a surprise', it is obvious and I'm pretty sure this had already been widely discussed months ago.
- Scoundreller 5y ago
  The problem is teasing out whether differences in vaccine effectiveness are due to the vaccine or which patients got which. I don’t think we’ve done any blinded head to head studies of one vs the other.
- native_samples 5y ago
  Obvious in what way? It wasn't obvious to governments. So far only the Nordics and France have banned Moderna (and only for the under 30s). And at the beginning, there was no mention of heart damage for anything.
  - staticassertion 5y ago
    Obvious that Moderna side effects would be more common given the larger dose. It's... obvious.

brundolf 5y ago

Wow I didn't realize that about the dose difference, I wondered why they gave us a half dose for our booster

Scoundreller 5y ago
What’s interesting is that in the initial trials, moderna tested 50, 100 and 250mcg in humans and ultimately decided on 100mcg as the sweet spot. https://www.nih.gov/news-events/news-releases/nih-clinical-trial-evaluating-moderna-covid-19-variant-vaccine-begins https://www.nih.gov/news-events/news-releases/nih-clinical-t... Meanwhile pfizer tested 10, 30 and 100 and ultimately settled on 30mcg as their sweet spot. https://www.nature.com/articles/s41586-020-2639-4 https://www.nature.com/articles/s41586-020-2639-4 Was this due to differences in the vaccine itself, different study environments, or different tolerances for the balance between side effects and effectiveness?

staticassertion 5y ago

It's more than 'not really a surprise', it is obvious and I'm pretty sure this had already been widely discussed months ago.

Scoundreller 5y ago
The problem is teasing out whether differences in vaccine effectiveness are due to the vaccine or which patients got which. I don’t think we’ve done any blinded head to head studies of one vs the other.
native_samples 5y ago
Obvious in what way? It wasn't obvious to governments. So far only the Nordics and France have banned Moderna (and only for the under 30s). And at the beginning, there was no mention of heart damage for anything.
- staticassertion 5y ago
  Obvious that Moderna side effects would be more common given the larger dose. It's... obvious.