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I'm not so certain. People who for whatever irrational reason don't want an mRNA vaccine can take a viral vector vaccine. Yet they don't.

by orra 5y ago

toast0 5y ago
Maybe if they're hesitant for irrational reasons. But if they're hesitant for rational reasons, mRNA vaccines and modified adenovirus vaccines are both new for mass use. There are some inactivated virus vaccines which would be best for people who want to avoid new vaccine types, but AFAIK they haven't even been tested in the US.
nijave 5y ago
Monoclonal antibodies get less pushback https://www.nytimes.com/2021/09/18/health/covid-antibody-regeneron.html https://www.nytimes.com/2021/09/18/health/covid-antibody-reg... I think there's also some "it won't happen to me" mentality that quickly disappears once it does (which is far too late for a vaccine)
claytongulick 5y ago
I suppose some people would lump me in with "anti-vaxxer" because I don't want to get the Covid vaccine. I'm not anti-vax, btw. I have a medical condition that requires me to receive regular vaccination against several diseases, and I'm strict about doing that on time. I've made a calculated decision in the case of this specific vaccine based on that fact that I've now had Covid twice (first time was a bit nasty, second time was very mild) and have acquired fairly robust natural immunity. According to almost all of the research I've read, natural immunity is at least as effective as the vaccine, which makes sense to me. Our bodies (if healthy) tend to be pretty good at this stuff. The vaccine carries risk, all medical treatments do. When I calculate my baseline risk - very healthy, fit, no cormobidities, etc..., couple it with my acquired natural immunity, my chances of a negative outcome from Covid asymptotically approach zero. This appears to me to be less risk than the vaccine introduces. I say all this to describe my mindset, I think a lot of people share it. Lumping everyone that choses based on a risk calculation to not receive the vaccine as "anti-vaxxer" is a common thing that people do (though I believe it is wrong). All that being said, my primary point is that if I got Covid again, I'd absolutely be receptive to a therapeutic like this. My decision against getting the vaccine was entirely risk based. At the point where I've contracted the illness again, however unlikely, the risk has been realized and I would 100% be receptive to taking this therapeutic if my doctor recommended it.
- oblio 5y ago
  The thing is, you're not representative of unvaccinated folks. You're an extreme outlier. Most of them haven't done this research. In my opinion, if you're nice and wear a mask in crowded conditions, don't go around hanging especially indoors in big groups, your position is kind of ok. Though I'd still look at the numbers to check if vaccines reduce infection rates and rate of spread. Because if that's true, it might be worth getting vaccinated to protect others a bit more.
  - mensetmanusman 5y ago
    Your priors probably need updating as natural immunity as the OP describes appears to be much more robust, esp compared to the J&J after a year. Also vaccinated people spread delta, so everyone is getting it on some time scale.
    - oblio 5y ago
      You > Your priors probably need updating as natural immunity as the OP describes appears to be much more robust, esp compared to the J&J after a year. Me > Though I'd still look at the numbers to check if vaccines reduce infection rates and rate of spread. Thankfully I said that already. > Also vaccinated people spread delta, so everyone is getting it on some time scale. That's not guaranteed, though. Just like not everyone on the planet will ever get all the strands of flu or cold or whatever. Through natural immunity + vaccinations at some point the disease can just die down and through a simple rotation you could avoid it (i.e. everyone else gets it at a time when you're not around so you're spared). Plus the time scale is important. In November 2019 we didn't have any vaccines, now we have 4 that are approved on a wide scale (Pfizer, Moderna, J&J, AZ) plus a bunch of others with widespread usage but a less stellar reputation (Sputnik, the Chinese ones) plus another bunch coming soon <<and>> this very topic is about a drug for curing it. And another slightly less effective drug has also been approved recently, from Merck. That's... 24 months after the initial outbreak. Who knows what 24 more months will bring?
    - orra 5y ago
      > Also vaccinated people spread delta Vaccinated people? Much less so than the unvaccinated. Double vaccinated people are 60-75% less likely to catch even asymptomatic COVID. If infected, they are 50% less likely to transmit it onwards to others. These are Delta figures.

I'm not so certain. People who for whatever irrational reason don't want an mRNA vaccine can take a viral vector vaccine. Yet they don't.

by orra 5y ago

I'm not so certain. People who for whatever irrational reason don't want an mRNA vaccine can take a viral vector vaccine. Yet they don't.

toast0 5y ago

Maybe if they're hesitant for irrational reasons. But if they're hesitant for rational reasons, mRNA vaccines and modified adenovirus vaccines are both new for mass use. There are some inactivated virus vaccines which would be best for people who want to avoid new vaccine types, but AFAIK they haven't even been tested in the US.

nijave 5y ago

Monoclonal antibodies get less pushback https://www.nytimes.com/2021/09/18/health/covid-antibody-regeneron.html https://www.nytimes.com/2021/09/18/health/covid-antibody-reg... I think there's also some "it won't happen to me" mentality that quickly disappears once it does (which is far too late for a vaccine)

claytongulick 5y ago

I suppose some people would lump me in with "anti-vaxxer" because I don't want to get the Covid vaccine. I'm not anti-vax, btw. I have a medical condition that requires me to receive regular vaccination against several diseases, and I'm strict about doing that on time. I've made a calculated decision in the case of this specific vaccine based on that fact that I've now had Covid twice (first time was a bit nasty, second time was very mild) and have acquired fairly robust natural immunity. According to almost all of the research I've read, natural immunity is at least as effective as the vaccine, which makes sense to me. Our bodies (if healthy) tend to be pretty good at this stuff. The vaccine carries risk, all medical treatments do. When I calculate my baseline risk - very healthy, fit, no cormobidities, etc..., couple it with my acquired natural immunity, my chances of a negative outcome from Covid asymptotically approach zero. This appears to me to be less risk than the vaccine introduces. I say all this to describe my mindset, I think a lot of people share it. Lumping everyone that choses based on a risk calculation to not receive the vaccine as "anti-vaxxer" is a common thing that people do (though I believe it is wrong). All that being said, my primary point is that if I got Covid again, I'd absolutely be receptive to a therapeutic like this. My decision against getting the vaccine was entirely risk based. At the point where I've contracted the illness again, however unlikely, the risk has been realized and I would 100% be receptive to taking this therapeutic if my doctor recommended it.

oblio 5y ago
The thing is, you're not representative of unvaccinated folks. You're an extreme outlier. Most of them haven't done this research. In my opinion, if you're nice and wear a mask in crowded conditions, don't go around hanging especially indoors in big groups, your position is kind of ok. Though I'd still look at the numbers to check if vaccines reduce infection rates and rate of spread. Because if that's true, it might be worth getting vaccinated to protect others a bit more.
- mensetmanusman 5y ago
  Your priors probably need updating as natural immunity as the OP describes appears to be much more robust, esp compared to the J&J after a year. Also vaccinated people spread delta, so everyone is getting it on some time scale.
  - oblio 5y ago
    You > Your priors probably need updating as natural immunity as the OP describes appears to be much more robust, esp compared to the J&J after a year. Me > Though I'd still look at the numbers to check if vaccines reduce infection rates and rate of spread. Thankfully I said that already. > Also vaccinated people spread delta, so everyone is getting it on some time scale. That's not guaranteed, though. Just like not everyone on the planet will ever get all the strands of flu or cold or whatever. Through natural immunity + vaccinations at some point the disease can just die down and through a simple rotation you could avoid it (i.e. everyone else gets it at a time when you're not around so you're spared). Plus the time scale is important. In November 2019 we didn't have any vaccines, now we have 4 that are approved on a wide scale (Pfizer, Moderna, J&J, AZ) plus a bunch of others with widespread usage but a less stellar reputation (Sputnik, the Chinese ones) plus another bunch coming soon <<and>> this very topic is about a drug for curing it. And another slightly less effective drug has also been approved recently, from Merck. That's... 24 months after the initial outbreak. Who knows what 24 more months will bring?
  - orra 5y ago
    > Also vaccinated people spread delta Vaccinated people? Much less so than the unvaccinated. Double vaccinated people are 60-75% less likely to catch even asymptomatic COVID. If infected, they are 50% less likely to transmit it onwards to others. These are Delta figures.