> this ends up looking like the quantum physics conundrum where there is a central tendency rather than certainty, until you pin it down in some way. Yes, this

> this ends up looking like the quantum physics conundrum where there is a central tendency rather than certainty, until you pin it down in some way. Yes, this is always true. Entropy is real, and loss of entropy affects free energy of binding. Even "structures" aren't really structures, but instantaneous pictures of a system in constant motion.