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Great link, summarizing recent research showing strong post-vaccination long-term B cell response. Then Twitter surfaces a recent breakthrough infection study
by angelzen 5y ago
Great link, summarizing recent research showing strong post-vaccination long-term B cell response.
Then Twitter surfaces a recent breakthrough infection study among 620k US veterans in the "More Tweets" section: https://twitter.com/EricTopol/status/1448815262522773520 https://twitter.com/EricTopol/status/1448815262522773520 After six months from initial vaccination (Mar-Aug) the J&J vaccine appears to have zero (!) VE against infection. Pfizer is holding at a modest 53% against infection. Worse, the curve has the same shape as J&J, merely 2 months delayed.
In spite of very promising cellular and molecular studies, I am left scratching my head: are the vaccines any good at preventing infection in the long term, where we define long term as a few years down the road? The question is somewhat rhetorical, as we don't have epi studies from 2025 yet.
PS. I am more than happy to make a distinction between infection and severe infection. The main reason I pay attention to VE against infection are vaccine mandates and the whole stigma buildup against unvaccinated people.
PS2. > the flu vaccine, which for some reason doesn't attract the same sort of criticism.
People are free to get or not get a flu vaccine. Not getting a covid vaccine means loss of livelihood, loss of basic liberties and social ostracism.
- ashtonkem 5y ago> People are free to get or not get a flu vaccine. Not getting a covid vaccine means loss of livelihood, loss of basic liberties and social ostracism. Gee, I wonder if something happened recently that made stopping Covid more pressing than making everyone get a flu shot? Sure seems like there’s some reason, maybe a few hundred thousand reasons, why as a society we’re taking Covid and vaccination against it more seriously than the flu.
- orra 5y agoIt’s weird to be so focused on infection, when efficacy against severe disease is more practically relevant. And the latter remains high, around 92% or higher, even against Delta. Vaccine protection isn’t binary. Even if you end up infected your disease will be less severe AND you will be less contagious.
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- nradov 5y agoCOVID-19 vaccines aren't sterilizing to any meaningful extent. They provide only limited and temporary protection against infection. The real benefit is in protection against severe symptoms. https://www.nature.com/articles/d41586-021-02689-y https://www.nature.com/articles/d41586-021-02689-y https://www.businessinsider.com/delta-variant-made-herd-immunity-not-possible-astrazeneca-developer-2021-8?r=US&IR=T https://www.businessinsider.com/delta-variant-made-herd-immu...