19 ms·

As far as I can tell ivermectin has only been "studied" against TMPRSS2 in silico. The better-studied purported mechanism of ivermectin against SARS-CoV-2 invol

As far as I can tell ivermectin has only been "studied" against TMPRSS2 in silico. The better-studied purported mechanism of ivermectin against SARS-CoV-2 involves something called importin [1]. On the other hand, bromhexine, which is a cough medicine used OTC around the world does inhibit TMPRSS2 and may have action against SARS-Cov-2 [2]. Bromhexine is a prodrug for ambroxol, which is also an OTC cold medicine in much of the world. [1] https://pubmed.ncbi.nlm.nih.gov/32251768/ https://pubmed.ncbi.nlm.nih.gov/32251768/ [2] https://pubmed.ncbi.nlm.nih.gov/32983936/ https://pubmed.ncbi.nlm.nih.gov/32983936/

WithinReason 5y ago
> in silico you mean they only studied it in a computer simulation?
- weaksauce 5y ago
  correct
abecedarius 5y ago
Already in 2020 (I forget just how early), __ice9 on twitter was pointing out bromhexine and stressing the importance of blocking both ACE2 and TMPRSS2 binding ("dual-entry inhibition"). This is not an area I personally know about, but it's worth bringing up for the enthusiasts for censorship. https://twitter.com/__ice9/status/1368634545717788677 https://twitter.com/__ice9/status/1368634545717788677 If it works, the OTC nature is important. Hard for any drug to be very effective if the get-an-appointment-see-a-doctor-get-a-prescription-get-it-filled system takes you well past peak viral load before you even start using it.