There's some evidence that major mutations are happening in severely immunocompromised patients, since COVID is able to stick around longer. [0] The length of i

There's some evidence that major mutations are happening in severely immunocompromised patients, since COVID is able to stick around longer. [0] The length of infection seems to be one aspect allowing for evolutionary success of the virus: > A leading hypothesis is that these variants, characterized by a large number of nonsynonymous mutations, originated within individuals with long durations of infection during which the virus was subject to prolonged immune pressure (7, 8), and that this was potentially facilitated by the within-host emergence of deletions (49). [0] Consequently, some have suggested that monitoring for new strains might focus on such patients as a way to predict future adaptations in the wild, as scientist have observed some mutations re-occurring within immunocompromised individuals. So it might be possible to predict some mutations. [0] : https://www.nytimes.com/2021/03/15/health/coronavirus-variants-immunocompromised-patients.html https://www.nytimes.com/2021/03/15/health/coronavirus-varian... [1] : https://www.science.org/doi/full/10.1126/science.abg0821 https://www.science.org/doi/full/10.1126/science.abg0821