In terms of actual conflict no. There's been no large scale naval conflict since WW2. The closest is the Falklands war, which did show anti ship cruise missiles

In terms of actual conflict no. There's been no large scale naval conflict since WW2. The closest is the Falklands war, which did show anti ship cruise missiles can be effective, but is not a good basis for generalization. The Navy does do large scale wargaming exercises of course, though any of the interesting details aren't going to be public so that doesn't really help shed any light on it.