5 ms·
Thoughts that popped up: 1. Isn’t hyperbaric therapy used by athletes to reduce inflammation? 2. Isn’t the failure of the amyloid hypothesis leading to resear
by zzt123 5y ago
Thoughts that popped up:
1. Isn’t hyperbaric therapy used by athletes to reduce inflammation?
2. Isn’t the failure of the amyloid hypothesis leading to researchers considering whether inflammation is the progenitor of Alzheimer’s?
So if hyperbaric therapy does work… could that be a sign in favor of the inflammation hypothesis? Although, the authors suggest the results are due to improved oxygenation rather than any anti-inflammatory effects.
Also, I’m not a doctor nor am I educated in medical things.
- lambdaba 5y agoI think the etiology is best summed up as "energy deficiency", basically the mitochondria aren't able to provide enough energy. Nutritional repletion, ketogenic diets, ketone supplementation (specifically ketone esters) and everything else that improves energy supply / circumvents issues (impaired glucose metabolism being #1) will help.
- robbiep 5y agoThe amyloid hypothesis is not dead - just like the tau hypothesis is not dead. The $1m question is what role do the proteins play and at what stage and to what degree
- tcoff91 5y agoThere are so many plausible Alzheimer’s theories that it makes me wonder: are multiple of them right? Is Alzheimer’s really many different diseases that present the same way?
- robbiep 5y agoQuite possibly - however we haven't developed enough discerning power to differentiate between what may be a potential 'Alzheimer's Cluster' and say Fronto-temporal, Lewy Body, Vascular, etc etc.
- naasking 5y agoI assume "the amyloid hypothesis" is the hypothesis that plaques cause Alzheimer's. That hypothesis is indeed dead. There are plenty of successful plaque treatments. Basically none of them are effective.
- criddell 5y agoIs Wikipedia wrong? They say this: > Alzheimer's disease is believed to occur when abnormal amounts of amyloid beta, accumulating extracellularly as amyloid plaques, and tau proteins, accumulating intracellularly as neurofibrillary tangles, form in the brain affecting neuronal functioning and connectivity, resulting in a progressive loss of brain function.
- nradov 5y agoIt's not necessarily wrong, it's just unknown. There is no firm scientific consensus on that point.
- nradov 5y agoThere's a huge difference between the acute, localized inflammation from a sports injury versus the chronic, systemic inflammation associated with some metabolic diseases. Acute inflammation is actually a useful part of the healing process so we don't necessarily want to reduce it unless it's causing other problems. Hyperbaric oxygen therapy appears to be somewhat effective for accelerating healing certain soft tissue injuries. So athletes have used it. But it's not clear whether that therapy is any more effective than other recovery modalities. Research has been limited.