In the recent new season on Hulu there was an episode where Brain's future self arrived and wanted to kill Pinky for allegedly secretly sabotaging Brain's plans

In the recent new season on Hulu there was an episode where Brain's future self arrived and wanted to kill Pinky for allegedly secretly sabotaging Brain's plans all along. Some episodes could be interpreted that way, with Pinky screwing things up on purpose, but Brain clearly screws up himself much of the time.