6 ms·

High blood pressure, hypertension, obesity, and insulin resistance often come together. This hallmark combination is caused by the underlying metabolic dysfunct

High blood pressure, hypertension, obesity, and insulin resistance often come together. This hallmark combination is caused by the underlying metabolic dysfunction when the body is unable to consume the glucose in full despite it's more than adequate presence in the blood stream. Keyword: acquired mitochondrial disease. Moderate fasting, moderate physical activities, minerals (magnesium), and vitamins (especially B1, B3) help. The exception is a genetic form of mitochondrial disease which is generally incurable.

cinntaile 5y ago
> This hallmark combination is caused by the underlying metabolic dysfunction when the body is unable to consume the glucose in full despite it's more than adequate presence in the blood stream. Can you perhaps provide some sources to back your claim?
- garganzol 5y ago
  "Mitochondrial dysfunction leads to decreased β-oxidation and ATP production and increased ROS production, resulting in insulin resistance, diabetes, and cardiovascular disease." [2] [1] https://en.wikipedia.org/wiki/Glycolysis https://en.wikipedia.org/wiki/Glycolysis [2] https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.107.165472 https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.107.16547... [3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC380258/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC380258/ [4] https://en.wikipedia.org/wiki/Cellular_respiration https://en.wikipedia.org/wiki/Cellular_respiration
- mikenyc 5y ago
  https://www.amazon.com/Metabolical-Processed-Nutrition-Modern-Medicine/dp/0063027712/ https://www.amazon.com/Metabolical-Processed-Nutrition-Moder... p. 39-42 "the kidney is very adept at excreting excess sodium. But there’s one thing that inhibits sodium excretion by the kidney—insulin resistance. High insulin levels increase blood pressure, even with relatively low sodium intake. And many people are insulin resistant—and those people do need to lower their salt as a treatment of the disease."
  - virtuallynathan 5y ago
    Or they could lower carbohydrates, and reverse their insulin resistance.
    - nradov 5y ago
      Yes Virta Health has shown good clinical results with that approach. https://diabetes.diabetesjournals.org/content/67/Supplement_1/293-OR https://diabetes.diabetesjournals.org/content/67/Supplement_...
    - mikenyc 5y ago
      Correct, for most people. The book I quoted is by Dr Robert Lustig who is a leading voice on that point of view. He would more or less say insulin resistance is the root problem. Chronic conditions like hypertension are symptoms. The whole book is an argument in favor of curing the underlying metabolic disease with diet adjustment.
    - willmadden 5y ago
      Cutting out sugar and carbohydrates is key. Recommending lowering salt intake is a low priority when the root cause is usually insulin resistance/obesity.
nradov 5y ago
Mitochondrial disease can also be caused by some antibiotics. People tend to think of antibiotics as safe, but some of them can have drastic side effects. Mitochondria are basically bacteria that were incorporated into our cells through endosymbiosis so it's not surprising that treatments to kill off bacteria can also impact them. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760005/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760005/
goldforever 5y ago
100% - fix that insulin resistance first and the others will follow.

cinntaile 5y ago

> This hallmark combination is caused by the underlying metabolic dysfunction when the body is unable to consume the glucose in full despite it's more than adequate presence in the blood stream. Can you perhaps provide some sources to back your claim?

garganzol 5y ago
"Mitochondrial dysfunction leads to decreased β-oxidation and ATP production and increased ROS production, resulting in insulin resistance, diabetes, and cardiovascular disease." [2] [1] https://en.wikipedia.org/wiki/Glycolysis https://en.wikipedia.org/wiki/Glycolysis [2] https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.107.165472 https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.107.16547... [3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC380258/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC380258/ [4] https://en.wikipedia.org/wiki/Cellular_respiration https://en.wikipedia.org/wiki/Cellular_respiration
mikenyc 5y ago
https://www.amazon.com/Metabolical-Processed-Nutrition-Modern-Medicine/dp/0063027712/ https://www.amazon.com/Metabolical-Processed-Nutrition-Moder... p. 39-42 "the kidney is very adept at excreting excess sodium. But there’s one thing that inhibits sodium excretion by the kidney—insulin resistance. High insulin levels increase blood pressure, even with relatively low sodium intake. And many people are insulin resistant—and those people do need to lower their salt as a treatment of the disease."
- virtuallynathan 5y ago
  Or they could lower carbohydrates, and reverse their insulin resistance.
  - nradov 5y ago
    Yes Virta Health has shown good clinical results with that approach. https://diabetes.diabetesjournals.org/content/67/Supplement_1/293-OR https://diabetes.diabetesjournals.org/content/67/Supplement_...
  - mikenyc 5y ago
    Correct, for most people. The book I quoted is by Dr Robert Lustig who is a leading voice on that point of view. He would more or less say insulin resistance is the root problem. Chronic conditions like hypertension are symptoms. The whole book is an argument in favor of curing the underlying metabolic disease with diet adjustment.
  - willmadden 5y ago
    Cutting out sugar and carbohydrates is key. Recommending lowering salt intake is a low priority when the root cause is usually insulin resistance/obesity.

nradov 5y ago

Mitochondrial disease can also be caused by some antibiotics. People tend to think of antibiotics as safe, but some of them can have drastic side effects. Mitochondria are basically bacteria that were incorporated into our cells through endosymbiosis so it's not surprising that treatments to kill off bacteria can also impact them. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760005/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760005/

goldforever 5y ago

100% - fix that insulin resistance first and the others will follow.