4 ms·
Antigen targets aside, there is also a difference in the production of antibodies in the mucosal system. Current vaccines are intra muscular and lacks a robust
by anonuser123456 5y ago
Antigen targets aside, there is also a difference in the production of antibodies in the mucosal system.
Current vaccines are intra muscular and lacks a robust mucosal response while natural infection will provide mucosal immunity as well.
As one can imagine, mucosal immunity is very important in an upper respiratory track disease w.r.t. symptomatic infection and transmission.
- UncleOxidant 5y agoYeah, why aren't we putting more effort into getting an intranasal vaccine approved for emergency use? An intranasal vaccine would confer mucosal immunity and might also be more acceptable to the vaccine hesitant. They're talking about 3rd shot boosters, but I'd really like to be able to get an intranasal vaccine as the third booster.
- nradov 5y agoNasal vaccine trials are underway. We should have preliminary results in a few months. https://www.medpagetoday.com/special-reports/exclusives/92527 https://www.medpagetoday.com/special-reports/exclusives/9252...
- pettusftw 5y agoIIRC there is an intranasal expected to be approved mid next year. I can't find the source I read that in, so take the timing with a grain of salt. Another source I can't find at the moment mentioned questions about the duration of protection from that method of vaccination as well. I would guess the push for intramuscular was driven for multiple reasons, the first being ease of development and the second to keep hospitalizations and death at a minimum.
- jart 5y agoI don't think anyone's concerned about IM vs. IN as they are mRNA vs. DNA. The boosters deliver double stranded helix straight to the nucleus like a Windows update. You'd have to pull an Apocalypse Now to roll that back. GM people nobody panics but GM organic food and everyone loses their minds.
- fshbbdssbbgdd 5y agoI thought the boosters just have mRNA strands like the original mRNA vaccines do? I haven’t heard anything about them using CRISPR or otherwise editing the human genome. Would be neat but it seems like pharma companies charge a million dollars for that kind of treatment.
- empthought 5y agoYou don’t know how vaccines or viruses work, do you?
- jart 5y agoI know how code works and that DNA is code.
- empthought 5y agoEvery viral vaccine works this way, though. Because every virus works this way.
- jart 5y agoDon't most viruses just deliver mRNA that tells the cell to make more viruseses? I thought only a few, like herpes, deliver dna. That's why it can't be cured. DNA vaccines used to be commonly used on dogs and livestock to prevent things like rabies iiuc. It wasn't until these jensson booster shots that I've seen them being given to people on a large scale. Also there's a big difference when the mRNA and DNA code is emerging organically and when it's being engineering in labs.
- deleted 5y ago[deleted]