3 ms·

1) The number of Ox/AZ vaxes come far behind Pfizer, Moderna [0] 2) Mixing Ox/Az w/ mRNA vaccinations has been shown to be better than 2x Ox/Ax [1] 3) Pfizer,

1) The number of Ox/AZ vaxes come far behind Pfizer, Moderna [0] 2) Mixing Ox/Az w/ mRNA vaccinations has been shown to be better than 2x Ox/Ax [1] 3) Pfizer, Moderna, AZ/Covishield, and J&J are the only approved vaccines. Certainly no "soup of the day" [2] I hardly think any of this is "cringe". [0] https://www.canada.ca/en/public-health/services/diseases/2019-novel-coronavirus-infection/prevention-risks/covid-19-vaccine-treatment/vaccine-rollout.html#a4 https://www.canada.ca/en/public-health/services/diseases/201... [1] https://www.cbc.ca/news/health/mixing-vaccines-pfizer-astrazeneca-1.6083245 https://www.cbc.ca/news/health/mixing-vaccines-pfizer-astraz... [2] https://www.canada.ca/en/public-health/services/diseases/coronavirus-disease-covid-19/vaccines/what-expect-vaccination.html#a1 https://www.canada.ca/en/public-health/services/diseases/cor...

Anunayj 5y ago
Wow, that is certainly interesting!, gosh I wish we had more time to do deeper studies.
- dannyw 5y ago
  We easily could have done deeper studies. This is a highly parallelisable problem. The issue is all the regulatory red tape and extremely overburdening costs associated with clinical trials. After the initial safety trials showing that these vaccines have no significant adverse effects, we should have just gotten a dozen YOLO engineers and statisticians to run any permutation of dosage, duration, and vaccine candidate; much like how software companies run thousands of A/B tests at scale. It's a frigging pandemic with millions of deaths, there's no time to waste jacking off bureaucrats. Really, there's no good reason that clinical trials should cost $$$$-$$$$$ per participant. Here's how much it should cost: ~$20: targeted ads enrolling one participant ~$20: doses of the vaccine for one participant ~$30: distribution and logistics ~$100: human staffing and follow up ~$5: experiment analysis Instead, everything gets ballooned up by 10x or 50x because of arcane legislation. In the middle of a global pandemic.
  - darkteflon 5y ago
    Every time I read these blanket unsubstantiated claims about the evils of regulation, I’m reminded of Chesterton’s Fence: > There exists in such a case a certain institution or law; let us say, for the sake of simplicity, a fence or gate erected across a road. The more modern type of reformer goes gaily up to it and says, “I don’t see the use of this; let us clear it away.” To which the more intelligent type of reformer will do well to answer: “If you don’t see the use of it, I certainly won’t let you clear it away. Go away and think. Then, when you can come back and tell me that you do see the use of it, I may allow you to destroy it.”
  - deleted 5y ago
    [deleted]
  - jszymborski 5y ago
    > we should have just gotten a dozen YOLO engineers and statisticians to run any permutation of dosage, duration, and vaccine candidate; much like how software companies run thousands of A/B tests at scale. I, for one, would try to run clinical trials the total opposite from software companies. "Fail fast, fail often" nor "Iterate fast, release often" really work for healthcare.
Scoundreller 5y ago
While J&J was authorized in Canada, I don’t believe any were ever administered.
- k12sosse 5y ago
  We give/gave it to the homeless because, "good luck making sure they come back again for #2". Source: google it
  - salamandersauce 5y ago
    Source for that? Because the official Canadian government page on vaccine coverage clearly says the Janssen vaccine has yet to be administered in Canada and the only Canadians who got it got it outside the country. https://health-infobase.canada.ca/covid-19/vaccination-coverage/ https://health-infobase.canada.ca/covid-19/vaccination-cover...

Anunayj 5y ago

Wow, that is certainly interesting!, gosh I wish we had more time to do deeper studies.

dannyw 5y ago
We easily could have done deeper studies. This is a highly parallelisable problem. The issue is all the regulatory red tape and extremely overburdening costs associated with clinical trials. After the initial safety trials showing that these vaccines have no significant adverse effects, we should have just gotten a dozen YOLO engineers and statisticians to run any permutation of dosage, duration, and vaccine candidate; much like how software companies run thousands of A/B tests at scale. It's a frigging pandemic with millions of deaths, there's no time to waste jacking off bureaucrats. Really, there's no good reason that clinical trials should cost $$$$-$$$$$ per participant. Here's how much it should cost: ~$20: targeted ads enrolling one participant ~$20: doses of the vaccine for one participant ~$30: distribution and logistics ~$100: human staffing and follow up ~$5: experiment analysis Instead, everything gets ballooned up by 10x or 50x because of arcane legislation. In the middle of a global pandemic.
- darkteflon 5y ago
  Every time I read these blanket unsubstantiated claims about the evils of regulation, I’m reminded of Chesterton’s Fence: > There exists in such a case a certain institution or law; let us say, for the sake of simplicity, a fence or gate erected across a road. The more modern type of reformer goes gaily up to it and says, “I don’t see the use of this; let us clear it away.” To which the more intelligent type of reformer will do well to answer: “If you don’t see the use of it, I certainly won’t let you clear it away. Go away and think. Then, when you can come back and tell me that you do see the use of it, I may allow you to destroy it.”
- deleted 5y ago
  [deleted]
- jszymborski 5y ago
  > we should have just gotten a dozen YOLO engineers and statisticians to run any permutation of dosage, duration, and vaccine candidate; much like how software companies run thousands of A/B tests at scale. I, for one, would try to run clinical trials the total opposite from software companies. "Fail fast, fail often" nor "Iterate fast, release often" really work for healthcare.

Scoundreller 5y ago

While J&J was authorized in Canada, I don’t believe any were ever administered.

k12sosse 5y ago
We give/gave it to the homeless because, "good luck making sure they come back again for #2". Source: google it
- salamandersauce 5y ago
  Source for that? Because the official Canadian government page on vaccine coverage clearly says the Janssen vaccine has yet to be administered in Canada and the only Canadians who got it got it outside the country. https://health-infobase.canada.ca/covid-19/vaccination-coverage/ https://health-infobase.canada.ca/covid-19/vaccination-cover...