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The gut biome must be at least strongly influenced by the environment you create - change should be assumed as soon as you change that environment. But does th

The gut biome must be at least strongly influenced by the environment you create - change should be assumed as soon as you change that environment. But does the change mean anything? I think this is going to turn out to be an incomprehensible problem that we will never really get a handle on due to the time it would take to even begin to understand things. We just aren’t able to run those experiments and this is the general domain where science for us fails and degenerates to just-so stories and observational correlations “studies.” To illustrate… Last year I did 5 months of OMAD to lose weight. I’d gained a bunch in the first few months of lockdown. It wasn’t hard but it wasn’t easy especially because my wife, who is effortlessly slender and eats a ton, needs to eat a big breakfast every day. I often wonder if a gut biome transplant from her would give me that - I’d love to see someone actually do that experiment. But not on me. Her and her brother can literally eat bags of iced mothers cookies per week and stay slender - her GP says she needs to gain weight. It just isn’t going to happen. It took me awhile to understand what’s going on but my observation is they get really warm and fidgety for the hours after overeating and just burn it off sitting there. Her whole family is pretty lazy, they don’t exercise recreationally. They aren’t running it off or whatever. Whereas my chronically overweight family lives ends up with moderately high boood pressure, they also all live long lives mostly free of debilitating illness until the end. Her family, on the other hand, has all manner of terrible issues once they hit their 70s… Obviously this could just be “genetics” but whose? Their nuclear genetics or their inhabitants? And do the long terms come out of that? I honestly don’t think we will ever know without experiments. And given things like the above I wonder if they can be even done, even if you decided to ignore the potential long term…

beckingz 5y ago
OMAD = One Meal A Day
winrid 5y ago
Makes me wonder if having a higher metabolism somehow "wears out your body faster". My wife and I are the opposite. I can eat a cheeseburger every night and stay slender + low chloresterol etc. I do OMAD twice a week, which probably helps a little. It doesn't feel natural to always say three meals a day.
- foobiekr 5y ago
  I actually feel great doing OMAD as long as I eat by 3pm. That works great for me and I guess I should have mentioned that to tie up the fasting part of that post. I lose about 2lbs a week as long as I’m doing it, more if I stop lifting (which is exactly why I keep lifting while doing that). It’s just challenging in the context of real life. A friend wants to grab lunch, a friend wants to have dinner, my spouse the Cookie Monster is busy polishing off three eclairs next to me while I’m having my morning black coffee.
- dkdk8283 5y ago
  I recall a paper (I can’t locate it) associating high levels of metabolic activity with disease. For example if you have an incredibly physical job and put away 8000 calories daily but maintain a low BMI you suffer more cell damage. Similar for users of stimulant narcotics (legal or illegal). Perhaps a reader here is familiar with this study.
reedjosh 5y ago
There's a theory that the difference you're seeing is insulin tolerance. In your case, you're fat cells listen to the insulin and you gain weight. In your wife's case, her blood sugar probably runs higher as her fat cells aren't taking the excess. Getting fat acts as a sort of protection. You may be overweight, but healthier than a thin person eating junk.
- foobiekr 5y ago
  Totally, I accept this is true, but it’s possible imho that gut biome influences this. There’s also the fat distribution question. I often wonder about differences in visceral fat.
  - reedjosh 5y ago
    Yeah, it's definitely possible too. Could be that it affects digestive glycemic index.
- Seich 5y ago
  Do you have a source you can share for that? I’d love to read up on it. A cursory google search didn’t reveal much.
  - reedjosh 5y ago
    Unfortunately, no. It was a theory put forth by a researcher on a podcast. It makes complete sense to me, but I don't know how you'd even design an experiment for this. Maybe continues glucose monitoring along with identical diets for people of various body fat percentages?
  - tomasdore 5y ago
    Maybe it's this? Peter Attia https://www.youtube.com/watch?v=U3oI104STzs https://www.youtube.com/watch?v=U3oI104STzs especially from 8:45 when he talks of the people who stay thin (which is worse for them, if they actually are insulin resistant)
    - 5y ago
11235813213455 5y ago
> I often wonder if a gut biome transplant from her would give me that Our urine is charged with more or less of our gut biome, and enzymes, not only toxins. so maybe.. drinking it (some people do, at least it's not dangerous) You could consider switching diet to reshape your gut biome. Some people advise no-sugar diet, but in my case, I switched to a monkey diet, a lot of fruits, and lost a bit of weight (I used to be more 65-70kg for 1m83, now at 58kg) and gained energy, vitality, immunity (never ill), overall health, I can eat only fruits during some days or weeks. When there are less fruits I'd eat rice, lentils, honey, more rarely fish. So maybe try to switch your diet, find the one that works the best for you
- touisteur 5y ago
  58kg for 1m83 are you feeling OK? When I left home a 18 I was same size 55kg and I was... Very very thin. Pictures from then are kind of frightening. Not for lack of trying, though. I'd eat 300-500g (half a pack or the whole pack) of pasta 10 times a week, kilograms of cheese and looots of beer&wine, without ever taking 1kg on the weekly weight check...
  - 11235813213455 5y ago
    totally OK, I have thin members, for example I can join my thumb and index finger around my forearm. That's why the BMI scales are not really meaningful, because I'm not underweight. I'm 36 now, and know myself better, between 18 and 23 I was more around 65kg, then I changed diet to fruits (because I started unsold fruits and legumes, against food-waste), and never felt so energetic and good. 54kg starts to be underweight for me
    - touisteur 5y ago
      Happy for you then! I wasn't thinking BMI but worrying about a fellow very-thin/tall, from personal experience. I didn't feel 'bad' then when I was so thin, mostly I could eat anything in any quantity and feel fine. Things like 2 or 3 large pizzas and still room for desert... but when I look at pictures I didn't look very healthy. But yeah, each body/morphology is different :-). I think I messed up something with my hormones or something during my first year in college where I death-marched myself to study constantly until 5am, 'sleep' one hour or (luxury!) two and cold-shower myself into the next day, for 7 months. I felt so behind in everything and I hadn't learned to 'work' or 'study' in school, and I so afraid to fail and be poor fir life that I drained every ounce of anything I had to get by... Summerbreak of that first year in college, once exams and projects were done, I slept for 2 months, mostly waking up to eat, play console, read and go back to sleep... That september I was 130kg (from 55kg, still I have the stretch marks) it didn't hit me until November that my body had changed. Strangest thing then: I had gained so much muscle! I still don't really understand why. End of puberty I guess, but all so fast!

beckingz 5y ago

OMAD = One Meal A Day

winrid 5y ago

Makes me wonder if having a higher metabolism somehow "wears out your body faster". My wife and I are the opposite. I can eat a cheeseburger every night and stay slender + low chloresterol etc. I do OMAD twice a week, which probably helps a little. It doesn't feel natural to always say three meals a day.

foobiekr 5y ago
I actually feel great doing OMAD as long as I eat by 3pm. That works great for me and I guess I should have mentioned that to tie up the fasting part of that post. I lose about 2lbs a week as long as I’m doing it, more if I stop lifting (which is exactly why I keep lifting while doing that). It’s just challenging in the context of real life. A friend wants to grab lunch, a friend wants to have dinner, my spouse the Cookie Monster is busy polishing off three eclairs next to me while I’m having my morning black coffee.
dkdk8283 5y ago
I recall a paper (I can’t locate it) associating high levels of metabolic activity with disease. For example if you have an incredibly physical job and put away 8000 calories daily but maintain a low BMI you suffer more cell damage. Similar for users of stimulant narcotics (legal or illegal). Perhaps a reader here is familiar with this study.

reedjosh 5y ago

There's a theory that the difference you're seeing is insulin tolerance. In your case, you're fat cells listen to the insulin and you gain weight. In your wife's case, her blood sugar probably runs higher as her fat cells aren't taking the excess. Getting fat acts as a sort of protection. You may be overweight, but healthier than a thin person eating junk.

foobiekr 5y ago
Totally, I accept this is true, but it’s possible imho that gut biome influences this. There’s also the fat distribution question. I often wonder about differences in visceral fat.
- reedjosh 5y ago
  Yeah, it's definitely possible too. Could be that it affects digestive glycemic index.
Seich 5y ago
Do you have a source you can share for that? I’d love to read up on it. A cursory google search didn’t reveal much.
- reedjosh 5y ago
  Unfortunately, no. It was a theory put forth by a researcher on a podcast. It makes complete sense to me, but I don't know how you'd even design an experiment for this. Maybe continues glucose monitoring along with identical diets for people of various body fat percentages?
- tomasdore 5y ago
  Maybe it's this? Peter Attia https://www.youtube.com/watch?v=U3oI104STzs https://www.youtube.com/watch?v=U3oI104STzs especially from 8:45 when he talks of the people who stay thin (which is worse for them, if they actually are insulin resistant)
  - 5y ago

11235813213455 5y ago

> I often wonder if a gut biome transplant from her would give me that Our urine is charged with more or less of our gut biome, and enzymes, not only toxins. so maybe.. drinking it (some people do, at least it's not dangerous) You could consider switching diet to reshape your gut biome. Some people advise no-sugar diet, but in my case, I switched to a monkey diet, a lot of fruits, and lost a bit of weight (I used to be more 65-70kg for 1m83, now at 58kg) and gained energy, vitality, immunity (never ill), overall health, I can eat only fruits during some days or weeks. When there are less fruits I'd eat rice, lentils, honey, more rarely fish. So maybe try to switch your diet, find the one that works the best for you

touisteur 5y ago
58kg for 1m83 are you feeling OK? When I left home a 18 I was same size 55kg and I was... Very very thin. Pictures from then are kind of frightening. Not for lack of trying, though. I'd eat 300-500g (half a pack or the whole pack) of pasta 10 times a week, kilograms of cheese and looots of beer&wine, without ever taking 1kg on the weekly weight check...
- 11235813213455 5y ago
  totally OK, I have thin members, for example I can join my thumb and index finger around my forearm. That's why the BMI scales are not really meaningful, because I'm not underweight. I'm 36 now, and know myself better, between 18 and 23 I was more around 65kg, then I changed diet to fruits (because I started unsold fruits and legumes, against food-waste), and never felt so energetic and good. 54kg starts to be underweight for me
  - touisteur 5y ago
    Happy for you then! I wasn't thinking BMI but worrying about a fellow very-thin/tall, from personal experience. I didn't feel 'bad' then when I was so thin, mostly I could eat anything in any quantity and feel fine. Things like 2 or 3 large pizzas and still room for desert... but when I look at pictures I didn't look very healthy. But yeah, each body/morphology is different :-). I think I messed up something with my hormones or something during my first year in college where I death-marched myself to study constantly until 5am, 'sleep' one hour or (luxury!) two and cold-shower myself into the next day, for 7 months. I felt so behind in everything and I hadn't learned to 'work' or 'study' in school, and I so afraid to fail and be poor fir life that I drained every ounce of anything I had to get by... Summerbreak of that first year in college, once exams and projects were done, I slept for 2 months, mostly waking up to eat, play console, read and go back to sleep... That september I was 130kg (from 55kg, still I have the stretch marks) it didn't hit me until November that my body had changed. Strangest thing then: I had gained so much muscle! I still don't really understand why. End of puberty I guess, but all so fast!