5 ms·

NMN supplementation enhances aerobic capacity: a randomized, double-blind study

31 points by voisin 5y ago

PaulHoule 5y ago
(1) It looks like a high-quality study for a supplement (won't get rejected by Cochrane out of hand.) (2) It's rare to see anything that improves aerobic performance, but this seems to
geedy 5y ago
Is this the kind of thing one can easily buy? Do we know how she it is for general use?
- nootropicat 5y ago
  You can buy niagen, which has nicotinamide riboside (NR), which is basically the same thing - the goal is to increase NAD+ in the mitochondria. NR is an immediate precursor to NMN which is NR with an added phosphate group, which makes NMN itself unlikely to enter any cell directly. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352172/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352172/
  - dr_kiszonka 5y ago
    Are there any affordable and reputable niagen products? On Amazon, it looks like 300 mg x 30 days costs ~$50.
- ganeshkrishnan 5y ago
  NMN is not approved yet but you can buy them online from reputed sellers. Check their 3rd party testing. Dont buy from Amazon/Ebay, some of independent tests came up with 0% NMN (so what are they?) Vitamin B3 also increases NMN level and is a precursor to NMN. It's probably better to just take nicacin (B3) as its safer until NMN is proven to be safe for human in longer doses. NMN is too large molecule to enter cells so anyway its broken down before it can be absorbed.
  - monktastic1 5y ago
    Are you aware of studies showing that B3 boosts NAD+? This summary (from last year) seems to suggest there is little to no such evidence: https://www.endocrinology.org/endocrinologist/135-spring20/features/nutrition-nad-and-exercise-vitamin-b3-supplements-to-stay-fit-and-healthy/ https://www.endocrinology.org/endocrinologist/135-spring20/f... Edit: found at least one study since then, written about here. https://www.lifespan.io/news/niacin-increases-nad-significantly-in-human-trial/ https://www.lifespan.io/news/niacin-increases-nad-significan...
    - ganeshkrishnan 5y ago
      https://www.elysiumhealth.com/en-us/science-101/the-benefits-of-vitamin-b3 https://www.elysiumhealth.com/en-us/science-101/the-benefits... B3 is a precursor to NAD+ but you also need some amino acids to make it. Taking NMN directly also had some health issues that were discovered recently. More importantly it can speed up cancer if you are predisposed to it or if you already have undiagnosed cancer. as far as I can remember, one of the treatments of cancer is removing nmn from body.
      - deleted 5y ago
        [deleted]
LeonB 5y ago
In mice
- voisin 5y ago
  Did you read beyond the background? “This study investigates the effects of a combination of exercise training and supplementation with nicotinamide mononucleotide (NMN), the immediate precursor of NAD+, on cardiovascular fitness in healthy amateur runners”
  - vipa123 5y ago
    I think you know the answer...
  - cwillu 5y ago
    ‹mutters something about the rat race›
- Tenoke 5y ago
  Way to make people trust that normally important correction less by posting it where it doesn't apply.
- LeonB 5y ago
  My bad sorry. It was tested on humans.

31 points by voisin 5y ago

(1) It looks like a high-quality study for a supplement (won't get rejected by Cochrane out of hand.) (2) It's rare to see anything that improves aerobic performance, but this seems to

geedy 5y ago

Is this the kind of thing one can easily buy? Do we know how she it is for general use?

nootropicat 5y ago
You can buy niagen, which has nicotinamide riboside (NR), which is basically the same thing - the goal is to increase NAD+ in the mitochondria. NR is an immediate precursor to NMN which is NR with an added phosphate group, which makes NMN itself unlikely to enter any cell directly. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352172/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352172/
- dr_kiszonka 5y ago
  Are there any affordable and reputable niagen products? On Amazon, it looks like 300 mg x 30 days costs ~$50.
ganeshkrishnan 5y ago
NMN is not approved yet but you can buy them online from reputed sellers. Check their 3rd party testing. Dont buy from Amazon/Ebay, some of independent tests came up with 0% NMN (so what are they?) Vitamin B3 also increases NMN level and is a precursor to NMN. It's probably better to just take nicacin (B3) as its safer until NMN is proven to be safe for human in longer doses. NMN is too large molecule to enter cells so anyway its broken down before it can be absorbed.
- monktastic1 5y ago
  Are you aware of studies showing that B3 boosts NAD+? This summary (from last year) seems to suggest there is little to no such evidence: https://www.endocrinology.org/endocrinologist/135-spring20/features/nutrition-nad-and-exercise-vitamin-b3-supplements-to-stay-fit-and-healthy/ https://www.endocrinology.org/endocrinologist/135-spring20/f... Edit: found at least one study since then, written about here. https://www.lifespan.io/news/niacin-increases-nad-significantly-in-human-trial/ https://www.lifespan.io/news/niacin-increases-nad-significan...
  - ganeshkrishnan 5y ago
    https://www.elysiumhealth.com/en-us/science-101/the-benefits-of-vitamin-b3 https://www.elysiumhealth.com/en-us/science-101/the-benefits... B3 is a precursor to NAD+ but you also need some amino acids to make it. Taking NMN directly also had some health issues that were discovered recently. More importantly it can speed up cancer if you are predisposed to it or if you already have undiagnosed cancer. as far as I can remember, one of the treatments of cancer is removing nmn from body.
    - deleted 5y ago
      [deleted]

LeonB 5y ago

In mice

voisin 5y ago
Did you read beyond the background? “This study investigates the effects of a combination of exercise training and supplementation with nicotinamide mononucleotide (NMN), the immediate precursor of NAD+, on cardiovascular fitness in healthy amateur runners”
- vipa123 5y ago
  I think you know the answer...
- cwillu 5y ago
  ‹mutters something about the rat race›
Tenoke 5y ago
Way to make people trust that normally important correction less by posting it where it doesn't apply.
LeonB 5y ago
My bad sorry. It was tested on humans.