8 ms·
Another method which any able-bodied individual can try at home is multi day salt water fasting with multivitamin supplementation. Elevated levels of autophagy
by nszceta 5y ago
Another method which any able-bodied individual can try at home is multi day salt water fasting with multivitamin supplementation.
Elevated levels of autophagy after fasting result in the elimination of senescence-like neurons. Individual neurons of this type can negatively influence the extracellular environment and may promote induction of the same phenotype in surrounding cells, as well as driving aging and age-related diseases.
- tomrod 5y agoCitation(s)?
- TimSchumann 5y agohttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106288/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106288/ With the obligatory 'In Mice' addendum.
- tomrod 5y agoThanks.
- dna_polymerase 5y agoAlso worth checking out in the context: https://peterattiamd.com/the-mouse-trap-lost-in-translation/ https://peterattiamd.com/the-mouse-trap-lost-in-translation/
- el_dev_hell 5y agoThat sounds really interesting. Do you have any book recommendations that explain this process (ideally targeted at a non-medical audience)?
- lugged 5y agoNot a book but this does a good job exlaining it, https://youtu.be/FGoLcJxApCA https://youtu.be/FGoLcJxApCA
- totetsu 5y ago"the strong eat the weak", "autophagosomes are like soldiers", said my body builder standing in front of a "home farmstead" festooned set. .. this video is doing a lot more than explaining autophagy..
- lugged 5y agoWhat it does for you is between you and your YouTube overlords. For me, I try not to judge people for their body shape and listen to what they have to say regardless. The "festooned set" is a common thing across YouTube influencers and affiliate marketers, this guy particularly likes to push bone broth and other keto related stuff. Doesn't mean he isn't damn well versed in the subject matter though. If you like I can track down some old 3 hour long talks on autophagy and fasting if you'd prefer, those doc's are pretty funny too sometimes.
- totetsu 5y agoSorry if my comment seemed negative about the guy. Sometimes videos that have very marked signs like this one tickle my semiotics senses. It's a highly appealing video and I just wanted to pause and think why, and what other things it was transmitting.
- lugged 5y agoNot too negative, just wanted to make sure he was taken seriously, the amount of research and peer reviewed articles he covers in his videos is quite intensive, he doesn't half ass it at all.
- TimSchumann 5y agoI think 'The Cancer Code' by Dr. Jason Fung does a decent job of laying the groundwork.
- eyeball 5y agoThat guy is a quack.
- TimSchumann 5y agoI mean, he's a licensed practicing physician in Toronto, Ontario and nothing he advocates seems too far out of the mainstream medical science to me. Also, I just pulled out a copy of the book I mentioned, and in the appendix he's got 467 citations. I'd say ballpark over half of those are peer reviewed medical journals. Doesn't seem very duck-like, but I'm interested to hear your take on why he's a quack.
- dna_polymerase 5y agoDr Peter Attia is obsessed with the topic :) https://peterattiamd.com/tag/autophagy/ https://peterattiamd.com/tag/autophagy/
- 55555 5y agoIn other words, Jilly Juice. IME, there is always some nugget of truth behind bizarre public crazes.
- TimSchumann 5y agoYou actually don't need the multivitamin. Salt is essential though. Magnesium and Potassium are also really good supplements to add. But agree, fasting is great for cleaning up the biological cruft.
- dQw4w9WgXcQ 5y agoAnother potential positive benefit of fasting is it deprives the body of the energy/nutrients it needs to physiologically repress unexpressed emotions. Certainly if you have any past major traumas buried deep it may be beneficial to have someone well-fed along for the ride who can guide your thinking, but there's nothing quite like an extended fast to force you to jettison old cargo and take that ride on the emotional rollercoaster you've been avoidng for years.
- ww2buff 5y agoWhat is the physiological mechanism through which we repress unexpressed emotions, and which nutrients does it consume?
- dQw4w9WgXcQ 5y agoTry a 72-hr fast sometime and you'll have your answers and more!
- 14u2c 5y agoAh yes, hunger induced delirium.
- NiceWayToDoIT 5y agoNothing as special will happen after 72hrs of food fasting... humans can go on surprisingly long without food 8-42days and without food + water around 7 days.
- 14u2c 5y agoSure, you'll survive without lasting damage, but thinking such a fast itself won't impact your brain chemistry seems a bit much.
- NiceWayToDoIT 5y ago
- jk888 5y agoAny able bodied individual with a decent understanding of microbiology can grow some mushrooms too.
- miltondts 5y agoA quick google search seems to confirm that fasting can indeed help with depression: https://link.springer.com/article/10.1007/s12603-013-0344-9 https://link.springer.com/article/10.1007/s12603-013-0344-9 https://www.sciencedirect.com/science/article/pii/S0278584620305224?casa_token=zm05ZTGMdz4AAAAA:AHD1sROym09FRBQfy0O4DZ5HQObtP1SlE3GRPcKDrKRVzdOB6Q4ssvtuJ-lChTKsN7ZoxFJ2aw https://www.sciencedirect.com/science/article/pii/S027858462...
- me_me_me 5y agoDid multiple quite few 5 days fast, the max i got to was 10 days. I experienced none of the effects. People claim to be sharper and more energised during fast, but all I experienced was noticeable sluggishness (no glucose, only fat as energy source) and bit more pissy about small things (though I recognise it and never act on it). P.S. Worth mentioning, any water fast above 4 days can be potentially dangerous if you don't take supplements that regulate your bodily functions, like salt, potassium, magnesium etc. I have read accounts of people doing only water fast no supplements for 10-15 days and report serious symptoms of their body shutting down (maily cells dying due to lack of salt).
- nszceta 5y agoIn my experience it is dangerous to go more than a day without electrolyte and multivitamin supplementation. Care must be taken to avoid potassium overdose if supplementing with potassium. Sodium chloride is well tolerated on the order of no more than 20 grams per day spread out over the whole day.
- nradov 5y agoIf you can't go without multivitamin supplementation for a day then there's something medically wrong with your body.