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Aspirin could cut risk of death in cancer patients by 20%
- dstick 5y agoYour username is fitting in relation to the title ;-)
- csunbird 5y agoAspirin does prevent blood clots, right? Tumors are known to produce blood clots, maybe avoiding them improves the chances of survival.
- doggodaddo78 5y agoASpirin targets many different things. It should also be trialed against Triflusal, which an COX-1 irreversible inhibitor that is safer in some circumstances. https://en.wikipedia.org/wiki/Triflusal https://en.wikipedia.org/wiki/Triflusal https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931664/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931664/
- rakhodorkovsky 5y agoAspirin binds to PPARα to stimulate hippocampal plasticity and protect memory [1] Low-Dose Aspirin Upregulates Tyrosine Hydroxylase and Increases Dopamine Production in Dopaminergic Neurons: Implications for Parkinson’s Disease [2] [1] https://doi.org/10.1073/pnas.1802021115 https://doi.org/10.1073/pnas.1802021115 [2] https://doi.org/10.1007/s11481-018-9808-3 https://doi.org/10.1007/s11481-018-9808-3
- AnthonBerg 5y ago!
- hypertele-Xii 5y agoWhat is your comment supposed to mean?
- loonster 5y agoProbably a way for him to "Save" the comment. Typing "Thank You!" would have been more effective and less awkward.
- piva00 5y agoHacker News allows anyone with an account to favorite a comment, no need to comment on it to save it. Bookmarks are also a thing for a while.
- AnthonBerg 5y agoIn this context, an exclamation mark by itself stands for feelings of surprise and importance. It is purposefully not a like or upvote or a bookmark – it is a declaration of importance of the parent comment.
- tediousdemise 5y agoNext week’s headline: Aspirin raises cancer risk by 20%
- tediousdemise 5y agoI thought I was joking… https://www.healthline.com/health-news/a-low-dose-aspirin-daily-use-could-increase-cancer-risk-for-seniors https://www.healthline.com/health-news/a-low-dose-aspirin-da...
- jhloa2 5y agoThis is a perfect example of why our current media feels so exhausting. There's so many conflicting viewpoints and studies that all seem reasonable.
- shadilay 5y agoWith a low enough sample size anything can be true.
- athenot 5y agoIt's exhausting because the stories exaggerate the findings. Most everything in science is nuanced. Small sample, preliminary finding, caveats, unclear results… Really, this is more of an issue with modern storytelling which is often motivated to be sensational, or at least to present a relatable story.
- giantg2 5y agoOr in this case a meta study. It's hard to say how meaningful the results are because the purposes and methods of the underlying studies, meaning it's not likely they were designed to control for other factors that would impact what this study was looking at.
- anoncake 5y ago0.8*1.2 = 0.96, so that's a net 4% decrease in deaths :)
- gregjor 5y agoRisk of death always 100%.
- giantg2 5y agoRisk of death eventually 100%.
- nradov 5y agoIn cancer care by convention they look at 5 year survival rates.
- gregjor 5y agoI know. The headline is still wrong. Aspirin may improve one’s chance of living more than five years with cancer. Everyone will die, with or without cancer, with or without aspirin.
- 88840-8855 5y agoProbability of death of an individual is on average 100%. Edit: honestly, how autistic can one be to vote this down? lol
- cortic 5y agoprobability of death of an individual is under 100%, as not everyone is dead yet.
- doggodaddo78 5y agoWhat kind of cake?
- loa_in_ 5y agoRisk (a chance of an adverse event) of death always approaches 100% given enough time. Eventually the set of all possible events that can happen to you is smaller and smaller, and proportionally more of the probability space is occupied by events that lead to your death.
- Retric 5y agoThis is likely good news, but it’s important to understand context. In yet another case of optimizing for a metric, 5 year cancer survivor rate used to roughly equate to a cure. However, as more people are living longer in treatment with cancer, many things that only slightly slow death can look awesome while only adding a few months on average. For something as cheap and side effect free as Aspirin it’s likely an obvious choice. Just don’t except long term survival odds to improve as much as suggested.
- warmcat 5y agoI have been taking baby aspirin since I had a colon cancer scare after my doctor advised me to. After a lot of literature reading, daily low dose aspirin therapy seems to be a good way to take care of your health.
- doggodaddo78 5y agoIf you can reduce inflammation systematically through numerous holistic means, you probably are going to live longer and better. My intuition says that excessive inflammation, mechanical wear, or other repeated injuries at any scale are cancer/death fuel.
- jgrahamc 5y agoWhat sort of "colon cancer scare" resulted in you taking baby aspirin?
- bzaidan 5y agoMesalazine aka 5-ASA is an medication used to treat ulcerative colitis, crohn's and co. It's molecule is very similar to Aspirin. In fact, mesalazine is basically a localised form of aspirin for the gut. That's the logic I see in my head
- bitwize 5y agoSome doctors refer to salicylic acid as "vitamin S" because of its myriad of positive health effects.
- moritzwarhier 5y agoI take 100mg almost daily myself, but some studies say that for people without a prior stroke, myocardial infarction or Angina pectoris it can even be harmful. [1][2] According to most general physicians here in Germany I shouldn't be taking it as a person without said medical history. I don't plan to continue taking daily Asprin when I have met my weight loss and exercise goals. This new evidence for benefits with cancer patients is very interesting. Studies like that are hard to judge as a layman, meta-studies even more so. [2] found: > Cancer was the major contributor to the higher mortality in the aspirin group, accounting for 1.6 excess deaths per 1000 person-years. Cancer-related death occurred in 3.1% of the participants in the aspirin group and in 2.3% of those in the placebo group In addition there's the risk of gastrointestinal bleeding. [1] https://www.nejm.org/doi/full/10.1056/NEJMoa1803955 https://www.nejm.org/doi/full/10.1056/NEJMoa1803955 [2] https://www.sciencedirect.com/science/article/pii/S2213177917306844 https://www.sciencedirect.com/science/article/pii/S221317791...
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