3 ms·
Everyone seems to be focusing on your first comment at the dose must to be limited to 30 µg to avoid lipid toxicities. But the second issue is an even bigger is
by jostmey 5y ago
Everyone seems to be focusing on your first comment at the dose must to be limited to 30 µg to avoid lipid toxicities. But the second issue is an even bigger issue—-the immune system will remove cells expressing proteins not found in the patient’s genome.
- catlifeonmars 5y agoUnder what circumstances does this occur? Is this something the cell itself signals to the immune system?
- dekhn 5y agoit's one of the most extraordinary details I've learned in biology. The thymus expresses cell types from around the body and trains the immune system to not recognize them as foreign: https://en.wikipedia.org/wiki/Central_tolerance https://en.wikipedia.org/wiki/Central_tolerance it's not for genes, but for epitopes