4 ms·
It’s editing the genes of the cells of the liver, so presumably when those liver cells divide and multiply, the change would also be copied along as well. What
by rolleiflex 5y ago
It’s editing the genes of the cells of the liver, so presumably when those liver cells divide and multiply, the change would also be copied along as well.
What isn’t clear to me is that if this is targeted at the liver cells in particular, or splicing it for every cell in the body. In other words, this could be a germline mutation (passed to children) or it could be a somatic mutation (no change to future children), it depends on how targeted the treatment was.
- kaba0 5y agoEven if it is not specific, I would believe gametes are not affected/can be easily excludes due to the blood-testis barrier.
- wgolsen 5y agoWhen administered IV, most LNPs of this type are highly selective for hepatocytes. This edit cannot be passed on as no germ cells will be transfected.