3 ms·
Is this a one-time treatment? Does it remove all of the offending genetic material, and then when those cells divide they are cured? Or does it require ongoing
by noveltyaccount 5y ago
Is this a one-time treatment? Does it remove all of the offending genetic material, and then when those cells divide they are cured? Or does it require ongoing treatment?
- rolleiflex 5y agoIt’s editing the genes of the cells of the liver, so presumably when those liver cells divide and multiply, the change would also be copied along as well. What isn’t clear to me is that if this is targeted at the liver cells in particular, or splicing it for every cell in the body. In other words, this could be a germline mutation (passed to children) or it could be a somatic mutation (no change to future children), it depends on how targeted the treatment was.
- kaba0 5y agoEven if it is not specific, I would believe gametes are not affected/can be easily excludes due to the blood-testis barrier.
- wgolsen 5y agoWhen administered IV, most LNPs of this type are highly selective for hepatocytes. This edit cannot be passed on as no germ cells will be transfected.
- drran 5y agoPatient will need to do it once per 1,5-2 years. See https://www.youtube.com/watch?v=aoczYXJeMY4 https://www.youtube.com/watch?v=aoczYXJeMY4 .