6 ms·

This, TAME and TRIIM-X trials are the humanity's best hope (in the short term) to live longer. Until then, keep exercising, maintaining a healthy weight, and se

This, TAME and TRIIM-X trials are the humanity's best hope (in the short term) to live longer. Until then, keep exercising, maintaining a healthy weight, and seeing your Dr regularly. Fasting too helps!

saalweachter 5y ago
TBH I'd probably be more excited about a pill that let me hit a healthy 90 while never exercising and eating all the bread and bacon, than one that let me hit 150 with healthy living.
- epmaybe 5y ago
  This is one of those things that feels relative, in that we keep pushing the age of "good health" further and further as we, well, get healthier. What's if when you're 90 and healthy that you say, "it'd be nice if I could just take a pill and live to 150"?
  - saalweachter 5y ago
    I mean, sure, great. But you can't enjoy years 90-150 without first surviving years 30-90. Humans are statistically bad at doing the simple things that would help us live longer, like eating right, exercising regularly, and getting enough sleep. Most of us aren't going to make it to 90, and it's about half-and-half cancer versus heart disease what will kill us along the way. Sure, I could exercise regularly, etc, and maybe reduce my chance of dying before 90, but as a statistical American there's an 80% chance I'm not gonna, and a 40% chance it will kill me. Hence, I'd be much more excited if they could fix that with a pill. Fixing the dying of "old age" as my cellular machinery slowly degrads, also good, but I've got to survive long enough for that to be a problem first.
    - chii 5y ago
      It's a choice that people make to _not_ exercise and eat healthy.
    - amanaplanacanal 5y ago
      Past of the problem is that it is unclear what eating healthy means. Exercise seems to be good though, as far as we can tell.
      - pps 5y ago
        Just in case you wasn't aware of this book and his research and studies: https://www.amazon.com/Longevity-Diet-Discover-Activation-Regeneration/dp/0525534075 https://www.amazon.com/Longevity-Diet-Discover-Activation-Re...
- buu700 5y ago
  I hear this sentiment a lot, and of course respect your position, but I think it's a lot easier to say this when 90 and 150 both feel inconceivably far away. Personally, I'd be perfectly happy eating my bacon with low-carb bread for my entire life and working out a couple times a week if it guaranteed an extra 60 healthy years (although I'm biased because I already do both of those things).
  - burnished 5y ago
    Nah,I don't do any of that shit but if I felt it was guaranteed I do as you do.
- melling 5y ago
  That additional 60 years gets many people well into the 22nd century. Making it to 2130 could buy one an extra 20-30 years.
  - redler 5y ago
    The extra 60 could get you just over the big hump.
- wyxuan 5y ago
  Novo Nordisk's recently approved Wegovy works pretty well for your latter use case, and they're undergoing clinical trials for oral medication (it's currently administered via IV). iirc, the side effect profile was pretty mild nausea, so definitely a viable option if you're in the market for FDA approved weight loss/control drugs
- xvector 5y ago
  That is very easy to say until you are 90 and on your deathbed. I guarantee you that if you were moments from entering that eternal and infinite void, and someone offered you a rewind button to take the second path, you would press it in an instant.
  - saalweachter 5y ago
    But what if I take that second path, and die at age 60 of a heart attack, because cake is delicious and cardiovascular exercise is 30 minutes a day I can't do other stuff?
xvector 5y ago
Do you have links to these initiatives? (TAME and TRIIM-X)
- starchild_3001 5y ago
  https://www.afar.org/tame-trial https://www.afar.org/tame-trial https://www.google.com/search?q=TRIIM-X+trial https://www.google.com/search?q=TRIIM-X+trial

saalweachter 5y ago

TBH I'd probably be more excited about a pill that let me hit a healthy 90 while never exercising and eating all the bread and bacon, than one that let me hit 150 with healthy living.

epmaybe 5y ago
This is one of those things that feels relative, in that we keep pushing the age of "good health" further and further as we, well, get healthier. What's if when you're 90 and healthy that you say, "it'd be nice if I could just take a pill and live to 150"?
- saalweachter 5y ago
  I mean, sure, great. But you can't enjoy years 90-150 without first surviving years 30-90. Humans are statistically bad at doing the simple things that would help us live longer, like eating right, exercising regularly, and getting enough sleep. Most of us aren't going to make it to 90, and it's about half-and-half cancer versus heart disease what will kill us along the way. Sure, I could exercise regularly, etc, and maybe reduce my chance of dying before 90, but as a statistical American there's an 80% chance I'm not gonna, and a 40% chance it will kill me. Hence, I'd be much more excited if they could fix that with a pill. Fixing the dying of "old age" as my cellular machinery slowly degrads, also good, but I've got to survive long enough for that to be a problem first.
  - chii 5y ago
    It's a choice that people make to _not_ exercise and eat healthy.
  - amanaplanacanal 5y ago
    Past of the problem is that it is unclear what eating healthy means. Exercise seems to be good though, as far as we can tell.
    - pps 5y ago
      Just in case you wasn't aware of this book and his research and studies: https://www.amazon.com/Longevity-Diet-Discover-Activation-Regeneration/dp/0525534075 https://www.amazon.com/Longevity-Diet-Discover-Activation-Re...
buu700 5y ago
I hear this sentiment a lot, and of course respect your position, but I think it's a lot easier to say this when 90 and 150 both feel inconceivably far away. Personally, I'd be perfectly happy eating my bacon with low-carb bread for my entire life and working out a couple times a week if it guaranteed an extra 60 healthy years (although I'm biased because I already do both of those things).
- burnished 5y ago
  Nah,I don't do any of that shit but if I felt it was guaranteed I do as you do.
melling 5y ago
That additional 60 years gets many people well into the 22nd century. Making it to 2130 could buy one an extra 20-30 years.
- redler 5y ago
  The extra 60 could get you just over the big hump.
wyxuan 5y ago
Novo Nordisk's recently approved Wegovy works pretty well for your latter use case, and they're undergoing clinical trials for oral medication (it's currently administered via IV). iirc, the side effect profile was pretty mild nausea, so definitely a viable option if you're in the market for FDA approved weight loss/control drugs
xvector 5y ago
That is very easy to say until you are 90 and on your deathbed. I guarantee you that if you were moments from entering that eternal and infinite void, and someone offered you a rewind button to take the second path, you would press it in an instant.
- saalweachter 5y ago
  But what if I take that second path, and die at age 60 of a heart attack, because cake is delicious and cardiovascular exercise is 30 minutes a day I can't do other stuff?

xvector 5y ago

Do you have links to these initiatives? (TAME and TRIIM-X)

starchild_3001 5y ago
https://www.afar.org/tame-trial https://www.afar.org/tame-trial https://www.google.com/search?q=TRIIM-X+trial https://www.google.com/search?q=TRIIM-X+trial