3 ms·
Just jumping in to say that the successes of Pfizer/Moderna/AstraZeneca et al may have primed us to think that vaccines are usually successful but the reality
by vmurthy 5y ago
Just jumping in to say that the successes of Pfizer/Moderna/AstraZeneca et al may have primed us to think that vaccines are usually successful but the reality is that these are the exceptions (happy ones!) [0] . I can't find the exact source but most clinical trials don't even move to Phase-3. So failures like CureVac - while sad news indeed - happen :(
[0]https://www.centerwatch.com/articles/12702-new-mit-study-puts-clinical-research-success-rate-at-14-percent https://www.centerwatch.com/articles/12702-new-mit-study-put...
- vladimirralev 5y agoI wonder if it's possible that CureVac had to take some extra risks to be competitive this late in the race. With the Pfeizer/Moderna results already in, may be they aimed to deliver a lower dose vaccine with less side effects that would be more desirable, but that didn't pay off.
- itsdrewmiller 5y agoVaccines usually are successful (like 80% in phase 3 make it out?) - it’s cancer drugs that ruin the averages since they are very common and never work.