60 ms·
Hey, we make can NAD+ ourselves, you just have to get the Quinolinic pathway flowing: https://www.researchgate.net/figure/Overview-of-the-kynurenine-pathway-of
by podgaj 5y ago
Hey, we make can NAD+ ourselves, you just have to get the Quinolinic pathway flowing:
https://www.researchgate.net/figure/Overview-of-the-kynurenine-pathway-of-tryptophan-metabolism-note-Key-enzymes-are_fig1_257350797 https://www.researchgate.net/figure/Overview-of-the-kynureni...
This is most important when you have any kind of inflammation since inflammation stimulates the IDO enzymes.
How do you do that? Probably with some of the cofactors of the enzymes in the pathway liken:
B6 for KYNU: https://www.uniprot.org/uniprot/Q16719 https://www.uniprot.org/uniprot/Q16719
Riboflavin for KMO: https://www.uniprot.org/uniprot/O15229 https://www.uniprot.org/uniprot/O15229
I really wish the researchers would start testing people for these deficiencies more regularly.
- lumost 5y agoOr even general blood screenings. I once went to the doctor for depression that was severe enough to affect work and marriage. I was fortunate that the doctor tested for B12 deficiency, a week of methylated b12 supplementation fully fixed my depression which hasn't returned in years. Turns out there is a genetic component to B12 deficiency, and other family members have been turning up with the same kind of thing. I wonder how many people get driven into expensive medication and treatment programs for relatively simple to treat vitamin/metabolic disorders.
- podgaj 5y agoAll true. I can’t tell you how many women I know we’re suffering from “depression” and then they found out they were severely iron deficient. In my opinion, all mood disorders are metabolic disorders so that’s what frustrates me about it all.