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Both my wife and I got the J&J shot before it was cancelled. We both had a period about 12 hours afterwards where we felt like we had a mild flu for about anoth

by grej 5y ago

Both my wife and I got the J&J shot before it was cancelled. We both had a period about 12 hours afterwards where we felt like we had a mild flu for about another 12 hours, then it was over and we’ve felt fine. Very happy with this decision.

deleted 5y ago
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hcurtiss 5y ago
If we're doing anecdata, I too had the J&J shot right before it was cancelled. Literally no symptoms whatsoever. Very happy with the "one and done" relative to my wife who will go in next week for the second Pfizer shot, which has clobbered everyone else in our neighborhood who took it.
- rel2thr 5y ago
  My anecdote is that I got the JJ and kinda regret it, this blood clot thing made me realize it’s pretty untested , I feel like they should be recommending everyone get a full panel blood test a week after to add more data. After the AZ issues there should have been more scrutiny of the early clot cases
  - deleted 5y ago
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    - deleted 5y ago
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  - ggm 5y ago
    Kind of untested: sorry that's just wrong. All these shots are tested by 40,000 or more people. The problems emerging now are in the one in 100,000 or more. Do the maths on the odds.
    - not2b 5y ago
      More like 1 in 500k. The CDC reports that as of April 21 there have been a total of 15 confirmed cases of this blood clotting condition among nearly eight million doses administered. You probably won't find an issue that rare if you test 40k people. https://www.scientificamerican.com/article/blood-clots-and-the-johnson-johnson-vaccine-what-we-know-so-far/ https://www.scientificamerican.com/article/blood-clots-and-t...
      - disgruntledphd2 5y ago
        The UK figures (where AZ has been the centerpiece of their programme) suggest about 1 in 250k, which is still a really small risk.
        NeutronStar 5y ago
        You have a higher chance of death if you drive in a car for 20h. I assume most people would have driven more than 20h in 2019. 20h of driving being not even 1.5k miles at highway speeds and the average car having 10k miles driven per year.
    - mssundaram 5y ago
      Compared to other vaccines, 40,000 is "kinda untested"
      - ggm 5y ago
        During a pandemic?
      - arcticbull 5y ago
        My research indicated that the median broad-scale vaccine phase III trial is about 22,000 people [1]. I've also seen the 3,000 to 6,000 person range for smaller trials [2]. [1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551877/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551877/ [2] https://www.theatlantic.com/health/archive/2020/10/what-successful-vaccine-trial-looks-like/616775/ https://www.theatlantic.com/health/archive/2020/10/what-succ...
  - m-p-3 5y ago
    The average risk of thrombosis the J&J and AstraZeneca vaccine have are between 1 in 100,000 to 1 in 250,000. To put some perspective, estrogen-based medication like the contraceptive pill have a risk of 1 in 1,000.
    - mikem170 5y ago
      Careful, You might be comparing apples and oranges... Contraceptive pill blood clot risk is for any type of blood clot, such as deep vein thrombosis, pulmonary embolism, etc [0]. The vaccine cerebral venous sinus thrombosis blood clot risk is something like 1 in 100k+ (as you mentioned), but during J&J FDA trials of 20k people there were 50% more blood clots of other various types in the vaccinated group [1] (15 blood clots in vaccinated group versus 10 in the placebo group, which the FDA did not consider statistically significant at the time) You may be comparing fatal-only vaccine blood clots to non-fatal contraception blood clots, and ignoring non-fatal vaccine blood clots. I'm not saying this to throw the vaccine under the bus, just pointing out that the comparison of the odds you presented might not be fair. [0] https://thefemedic.com/contraception/blood-clots-thrombosis-combined-contraceptive-pill/ https://thefemedic.com/contraception/blood-clots-thrombosis-... [1] https://www.cnn.com/2021/04/13/health/johnson-vaccine-blood-clots-cdc-fda/index.html https://www.cnn.com/2021/04/13/health/johnson-vaccine-blood-...
      - mlyle 5y ago
        > You may be comparing fatal-only vaccine blood clots to non-fatal contraception blood clots At the time vaccination was paused, here were 6 known cases of CVST, 2 fatal, in 6.8 million vaccinated. To come up with 1 in 250,000 like the OP, you need to consider only women (~3.5 million doses), count all cases (not just the fatalities), and assume more than half of the cases were not reported.
  - grandmczeb 5y ago
    > I feel like they should be recommending everyone get a full panel blood test a week after to add more data. Why? That would that be a ridiculously impractical recommendation (do we even have the capacity to run millions of full panel blood tests a week?) and completely useless for detecting the problems people are worried about. TTS[1] isn’t something subtle you need a blood test for. [1] https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2021-04-23/03-COVID-Shimabukuro-508.pdf https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-...
    - rel2thr 5y ago
      I don't know if we have capacity, thats a good call out. I just feel like more data is better, the scientist don't seem to understand the mechanism that causes this problem and why it affects a few people but not most. Your link links the problem to low platelet count, is the vaccine affecting platelets in other people but not enough to manifest the issue? Maybe more data could help figure out why it happened to those handful of people and not others. The J&J vaccine causes headaches and pains normally , I was down and out for a couple days, I could easily see someone with the issue thinking its normal and waiting too long to go in for help.
  - quickthrowman 5y ago
    Who is going to pay for the blood panel?
- wincy 5y ago
  My anecdata, I got the J&J shot the Monday before it was cancelled. Went to sleep shivering that night. Felt better the next day, then terrible the day after that, then had an earth shattering headache like a bomb went off in my head the next day after that. Went to the ER at my wife’s insistence that they did a CT scan with the dye and all that. Said everything looks fine. I wasn’t having headaches before this but who knows maybe it’s just a coincidence. Sure seems like I’m getting a lot more headaches in the last couple weeks though.
cowmoo728 5y ago
Another anecdote: I took the J&J vaccine and felt shitty and tired for 4 days. I generally react this way to the flu vaccine too, so I was expecting it. I didn't experience anything else unusual, and I would still take the J&J vaccine again given the choice. I'm now completely back to normal.

by grej 5y ago

deleted 5y ago

[deleted]

hcurtiss 5y ago

If we're doing anecdata, I too had the J&J shot right before it was cancelled. Literally no symptoms whatsoever. Very happy with the "one and done" relative to my wife who will go in next week for the second Pfizer shot, which has clobbered everyone else in our neighborhood who took it.

rel2thr 5y ago
My anecdote is that I got the JJ and kinda regret it, this blood clot thing made me realize it’s pretty untested , I feel like they should be recommending everyone get a full panel blood test a week after to add more data. After the AZ issues there should have been more scrutiny of the early clot cases
- deleted 5y ago
  [deleted]
  - deleted 5y ago
    [deleted]
- ggm 5y ago
  Kind of untested: sorry that's just wrong. All these shots are tested by 40,000 or more people. The problems emerging now are in the one in 100,000 or more. Do the maths on the odds.
  - not2b 5y ago
    More like 1 in 500k. The CDC reports that as of April 21 there have been a total of 15 confirmed cases of this blood clotting condition among nearly eight million doses administered. You probably won't find an issue that rare if you test 40k people. https://www.scientificamerican.com/article/blood-clots-and-the-johnson-johnson-vaccine-what-we-know-so-far/ https://www.scientificamerican.com/article/blood-clots-and-t...
    - disgruntledphd2 5y ago
      The UK figures (where AZ has been the centerpiece of their programme) suggest about 1 in 250k, which is still a really small risk.
      - NeutronStar 5y ago
        You have a higher chance of death if you drive in a car for 20h. I assume most people would have driven more than 20h in 2019. 20h of driving being not even 1.5k miles at highway speeds and the average car having 10k miles driven per year.
  - mssundaram 5y ago
    Compared to other vaccines, 40,000 is "kinda untested"
    - ggm 5y ago
      During a pandemic?
    - arcticbull 5y ago
      My research indicated that the median broad-scale vaccine phase III trial is about 22,000 people [1]. I've also seen the 3,000 to 6,000 person range for smaller trials [2]. [1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551877/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551877/ [2] https://www.theatlantic.com/health/archive/2020/10/what-successful-vaccine-trial-looks-like/616775/ https://www.theatlantic.com/health/archive/2020/10/what-succ...
- m-p-3 5y ago
  The average risk of thrombosis the J&J and AstraZeneca vaccine have are between 1 in 100,000 to 1 in 250,000. To put some perspective, estrogen-based medication like the contraceptive pill have a risk of 1 in 1,000.
  - mikem170 5y ago
    Careful, You might be comparing apples and oranges... Contraceptive pill blood clot risk is for any type of blood clot, such as deep vein thrombosis, pulmonary embolism, etc [0]. The vaccine cerebral venous sinus thrombosis blood clot risk is something like 1 in 100k+ (as you mentioned), but during J&J FDA trials of 20k people there were 50% more blood clots of other various types in the vaccinated group [1] (15 blood clots in vaccinated group versus 10 in the placebo group, which the FDA did not consider statistically significant at the time) You may be comparing fatal-only vaccine blood clots to non-fatal contraception blood clots, and ignoring non-fatal vaccine blood clots. I'm not saying this to throw the vaccine under the bus, just pointing out that the comparison of the odds you presented might not be fair. [0] https://thefemedic.com/contraception/blood-clots-thrombosis-combined-contraceptive-pill/ https://thefemedic.com/contraception/blood-clots-thrombosis-... [1] https://www.cnn.com/2021/04/13/health/johnson-vaccine-blood-clots-cdc-fda/index.html https://www.cnn.com/2021/04/13/health/johnson-vaccine-blood-...
    - mlyle 5y ago
      > You may be comparing fatal-only vaccine blood clots to non-fatal contraception blood clots At the time vaccination was paused, here were 6 known cases of CVST, 2 fatal, in 6.8 million vaccinated. To come up with 1 in 250,000 like the OP, you need to consider only women (~3.5 million doses), count all cases (not just the fatalities), and assume more than half of the cases were not reported.
- grandmczeb 5y ago
  > I feel like they should be recommending everyone get a full panel blood test a week after to add more data. Why? That would that be a ridiculously impractical recommendation (do we even have the capacity to run millions of full panel blood tests a week?) and completely useless for detecting the problems people are worried about. TTS[1] isn’t something subtle you need a blood test for. [1] https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2021-04-23/03-COVID-Shimabukuro-508.pdf https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-...
  - rel2thr 5y ago
    I don't know if we have capacity, thats a good call out. I just feel like more data is better, the scientist don't seem to understand the mechanism that causes this problem and why it affects a few people but not most. Your link links the problem to low platelet count, is the vaccine affecting platelets in other people but not enough to manifest the issue? Maybe more data could help figure out why it happened to those handful of people and not others. The J&J vaccine causes headaches and pains normally , I was down and out for a couple days, I could easily see someone with the issue thinking its normal and waiting too long to go in for help.
- quickthrowman 5y ago
  Who is going to pay for the blood panel?
wincy 5y ago
My anecdata, I got the J&J shot the Monday before it was cancelled. Went to sleep shivering that night. Felt better the next day, then terrible the day after that, then had an earth shattering headache like a bomb went off in my head the next day after that. Went to the ER at my wife’s insistence that they did a CT scan with the dye and all that. Said everything looks fine. I wasn’t having headaches before this but who knows maybe it’s just a coincidence. Sure seems like I’m getting a lot more headaches in the last couple weeks though.

cowmoo728 5y ago

Another anecdote: I took the J&J vaccine and felt shitty and tired for 4 days. I generally react this way to the flu vaccine too, so I was expecting it. I didn't experience anything else unusual, and I would still take the J&J vaccine again given the choice. I'm now completely back to normal.