It would be really interesting to study the dose response curve in regard to a single thing like depression. Do microdoses or mild doses help more or less than

It would be really interesting to study the dose response curve in regard to a single thing like depression. Do microdoses or mild doses help more or less than a Zoom call with God dose? For a medical use I'd be concerned about the unpredictability of the experience with high doses. A traumatic or chaotic trip could make depression worse or possibly trigger other latent psychological issues.