4 ms·

Most of these studies just look at antibodies (because they are easiest to study) but all the indications are that T-cells from all vaccines will continue to wo

Most of these studies just look at antibodies (because they are easiest to study) but all the indications are that T-cells from all vaccines will continue to work well (thus preventing serious disease) because T-cells are much more comprehensive in their recognition abilities. So covid will try and evolve to keep spreading but it will become less deadly as vaccination and natural immunity increase. So its destiny is to become a cold virus like the other human coronaviruses. https://twitter.com/Coronavirusgoo1/status/1376928691473813512 https://twitter.com/Coronavirusgoo1/status/13769286914738135... https://twitter.com/Coronavirusgoo1/status/1366708675679764481 https://twitter.com/Coronavirusgoo1/status/13667086756797644... https://twitter.com/profshanecrotty/status/1355262019562209282 https://twitter.com/profshanecrotty/status/13552620195622092...

somewhereoutth 5y ago
That is just speculation I'm afraid. There is much evidence that newer variants are more contagious, more virulent, and affect younger people more severely. Brazil's experience is instructive. Thankfully the fantastic results of the mRNA vaccines mean that we should be able to suppress Covid down to the levels of measles, if not eradicate it like smallpox.
- codeulike 5y ago
  But it looks like none of those variants are going to be able to evade T-cells generated by existing vaccines or previous strains, thats my point.
  - raducu 5y ago
    The studies seem to suggest the existing antibodies produced by some vaccine are not effextive against some strains, is there any evidence T-cells will do better given the variant looks like a completely new virus to the immune system?
    - codeulike 5y ago
      Yes, lots of evidence. Look at my comment above.
      - deleted 5y ago
        [deleted]
      - raducu 5y ago
        Ok, I saw your twitter links, I just took the SA study regarding prior infection or AZ vaccination as a contrary proof, perhaps the fact that they didn't include any severe cases mean that both findings can be reconciled and that vaccines won't eradicate COVID-19 but rather it will become less severe over time.
__blockcipher__ 5y ago
SARS-2 was always destined to become yet another endemic seasonal respiratory virus, just to be clear. Also, it basically is a cold virus already. For the majority of the population it’s a mild respiratory virus. For the very elderly it is quite deadly. I wish more people appreciated this fact. Interestingly OC43, one of the already-extant human CoVs, seems pretty comparable in mortality for the elderly last time I checked.
- NicoJuicy 5y ago
  3 months ago, a friend of mine got it and he couldn't even walk the stairs. He's 34 and does a lot of sports. So, i wouldn't say that it's a cold virus already... Not deadly for younger people, doesn't mean it has no consequences.
  - tunnuz 5y ago
    As anecdotal as it can be, I also know people in their mid-thirties workout complicating pathologies and in good shape that ended up being treated in ICUs and on ventilation (one with a collapsed lung, pneumonia and a bacterial infection).
    - NicoJuicy 5y ago
      Well, i did mention it because it's not the only one I know. A friend of mine is a nurse and she also mentioned lots of young and fit collegues getting it pretty bad. But correct, no research. But mostly people i know they got infected. Sure, some have nothing or only lose smell and taste.
      - o-__-o 5y ago
        As someone who suffered long haul, I don’t know anyone in my social circle who came down with long symptoms besides me. So maybe it’s not as common as the medical journals describe?
        5y ago

somewhereoutth 5y ago

That is just speculation I'm afraid. There is much evidence that newer variants are more contagious, more virulent, and affect younger people more severely. Brazil's experience is instructive. Thankfully the fantastic results of the mRNA vaccines mean that we should be able to suppress Covid down to the levels of measles, if not eradicate it like smallpox.

codeulike 5y ago
But it looks like none of those variants are going to be able to evade T-cells generated by existing vaccines or previous strains, thats my point.
- raducu 5y ago
  The studies seem to suggest the existing antibodies produced by some vaccine are not effextive against some strains, is there any evidence T-cells will do better given the variant looks like a completely new virus to the immune system?
  - codeulike 5y ago
    Yes, lots of evidence. Look at my comment above.
    - deleted 5y ago
      [deleted]
    - raducu 5y ago
      Ok, I saw your twitter links, I just took the SA study regarding prior infection or AZ vaccination as a contrary proof, perhaps the fact that they didn't include any severe cases mean that both findings can be reconciled and that vaccines won't eradicate COVID-19 but rather it will become less severe over time.

__blockcipher__ 5y ago

SARS-2 was always destined to become yet another endemic seasonal respiratory virus, just to be clear. Also, it basically is a cold virus already. For the majority of the population it’s a mild respiratory virus. For the very elderly it is quite deadly. I wish more people appreciated this fact. Interestingly OC43, one of the already-extant human CoVs, seems pretty comparable in mortality for the elderly last time I checked.

NicoJuicy 5y ago
3 months ago, a friend of mine got it and he couldn't even walk the stairs. He's 34 and does a lot of sports. So, i wouldn't say that it's a cold virus already... Not deadly for younger people, doesn't mean it has no consequences.
- tunnuz 5y ago
  As anecdotal as it can be, I also know people in their mid-thirties workout complicating pathologies and in good shape that ended up being treated in ICUs and on ventilation (one with a collapsed lung, pneumonia and a bacterial infection).
  - NicoJuicy 5y ago
    Well, i did mention it because it's not the only one I know. A friend of mine is a nurse and she also mentioned lots of young and fit collegues getting it pretty bad. But correct, no research. But mostly people i know they got infected. Sure, some have nothing or only lose smell and taste.
    - o-__-o 5y ago
      As someone who suffered long haul, I don’t know anyone in my social circle who came down with long symptoms besides me. So maybe it’s not as common as the medical journals describe?
      - 5y ago