I'd say yes: https://www.pnas.org/content/111/45/15873 https://www.pnas.org/content/111/45/15873 But no, if one were being that particular brand of particular

I'd say yes: https://www.pnas.org/content/111/45/15873 https://www.pnas.org/content/111/45/15873 But no, if one were being that particular brand of particular that points out that amorphous aggregates are technically lower energy, which is true but not really interesting and kinda beside the point: https://www.researchgate.net/figure/Energy-landscape-of-protein-folding-and-aggregation-The-purple-surface-shows-possibility_fig1_330939850 https://www.researchgate.net/figure/Energy-landscape-of-prot... And yes, I'm sure there are uncountable exceptions in biology, but this is the generally mechanism of how it works, no?