5 ms·

It would be interesting to know if all inhaled steroids for asthmatics had a similar effect, or only this particular one. The steroid mentioned in this article

by jb1991 6y ago

It would be interesting to know if all inhaled steroids for asthmatics had a similar effect, or only this particular one. The steroid mentioned in this article is actually an older one, there are newer and more effective steroids that are often prescribed now. I wonder if they all work similarly in helping Covid patients. It would also be curious to know if people who are already taking the steroids have possible benefits for Covid illness, or if its main benefit is if it started at the onset of illness.

beagle3 6y ago
In the Oxford PR (and perhaps also in the medarxiv pre print, I don’t remember and am on phone now), it said the reason for starting this trial was that people with asthma are significantly underrepresented among COViD19 patients (you would expect them to be on par or even over represented as they start from a worse breathing baseline). Also, dexamethasone, a systemic steroid, seems to have comparable effects; likely, they both reduce or stop the damage from overactive immune response, which is likely a big part of covid complications.
- nradov 6y ago
  Recent research indicates that methylprednisolone is more effective than dexamethasone as a steroid treatment. https://doi.org/10.1101/2021.02.03.21251088 https://doi.org/10.1101/2021.02.03.21251088
AnthonBerg 6y ago
There seems to be a twist to budesonide: Inhaled budesonide regimen enhances serotonin- and arachidonic acid-induced platelet aggregation [via the 5-HT2A serotonin receptor?] – https://doi.org/10.1007/BF01991227 https://doi.org/10.1007/BF01991227
- tom_mellior 6y ago
  You posted this twice but failed to explain what the twist is.
  - AnthonBerg 6y ago
    Thank you for sharing your interpretation. For avoidance of doubt, this is the twist: Inhaled budesonide regimen enhances serotonin- and arachidonic acid-induced platelet aggregation [via the 5-HT2A serotonin receptor?] – https://doi.org/10.1007/BF01991227 https://doi.org/10.1007/BF01991227 Edit: In the light of downvotes - which I receive with kindness and in good spirits - then - again purely for avoidance of doubt - I want to confirm that this is the message.

by jb1991 6y ago

beagle3 6y ago

In the Oxford PR (and perhaps also in the medarxiv pre print, I don’t remember and am on phone now), it said the reason for starting this trial was that people with asthma are significantly underrepresented among COViD19 patients (you would expect them to be on par or even over represented as they start from a worse breathing baseline). Also, dexamethasone, a systemic steroid, seems to have comparable effects; likely, they both reduce or stop the damage from overactive immune response, which is likely a big part of covid complications.

nradov 6y ago
Recent research indicates that methylprednisolone is more effective than dexamethasone as a steroid treatment. https://doi.org/10.1101/2021.02.03.21251088 https://doi.org/10.1101/2021.02.03.21251088

AnthonBerg 6y ago

There seems to be a twist to budesonide: Inhaled budesonide regimen enhances serotonin- and arachidonic acid-induced platelet aggregation [via the 5-HT2A serotonin receptor?] – https://doi.org/10.1007/BF01991227 https://doi.org/10.1007/BF01991227

tom_mellior 6y ago
You posted this twice but failed to explain what the twist is.
- AnthonBerg 6y ago
  Thank you for sharing your interpretation. For avoidance of doubt, this is the twist: Inhaled budesonide regimen enhances serotonin- and arachidonic acid-induced platelet aggregation [via the 5-HT2A serotonin receptor?] – https://doi.org/10.1007/BF01991227 https://doi.org/10.1007/BF01991227 Edit: In the light of downvotes - which I receive with kindness and in good spirits - then - again purely for avoidance of doubt - I want to confirm that this is the message.